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Figure 13 | Virology Journal

Figure 13

From: Analysis of an ankyrin-like region in Epstein Barr Virus encoded (EBV) BZLF-1 (ZEBRA) protein: implications for interactions with NF-κB and p53

Figure 13

ZANK Ankyrin Switch Model. ZEBRA is proposed to have two distinct conformations depending on subcellular localization and DNA-binding. Left: When ZEBRA is bound to ZRE or AP-1 sites on DNA the two alpha helix strands are forced apart similar to the blades of an open scissors, preventing alignment of ZANK domains. Right: When ZEBRA is not bound to DNA either because of its cytoplasmic location or due to its binding to NF-κB and/or p53 proteins, the two alpha helices of the ZEBRA dimer can adopt a parallel or closed conformation similar to the parallel helices of ankyrin bound to NF-κB and/or p53 protein.

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