ZANK Structure with S205A polymorphism illustrated. A functionally conserved polymorphism in ZANK, A205 is altered to Ser is present in some EBV positive lymphoma cell lines such as Akata. A similar serine rather than alanine residue is present in some p53 binding protein ankyrin domains but not in NF-κB binding ankyrin domains. Changes in the stem or loop regions of ZANK could alter ZANK loop interactions with p53 and NF-κB particularly if covalently modified by serine phosphorylation. The circled region indicates a potential interaction between ZANK stem and loop amino acids.