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Table 3 Potential BoHV-4 V.test ORFs and homologues to HHV-8 and HHV-1

From: Sequencing of bovine herpesvirus 4 v.test strain reveals important genome features

BoHV-4 ORF Strand Starta Stopa HHV-8 homologueb HHV-1 homologuec Annotation and comments
Bo1 - 272 460 -- -- Early in-frame STOP codon
ORF 3 + 441 4307 -- -- BORFA1; v-FGAM-synthase
Bo2 + 4435 4638 -- --  
Bo3 + 5072 5299 -- --  
ORF 6 + 5703 9107 ORF 6 UL 29 single-stranded DNA-binding protein MDBP
ORF 7 + 9112 11190 ORF 7 UL 28 transport protein
ORF 8 + 11180 13804 ORF 8 UL 27 glycoprotein B
ORF 9 + 13944 16961 ORF 9 UL 30 DNA polymerase
ORF 10 + 17057 18337 ORF 10 -- BORFB1
Bo4 - 18604 19101 -- -- short ORF of immediate early transcript 1
Bo5 - 19170 20355 K5 -- long ORF of immediate early transcript 1
Bo6 + 20297 20590 -- -- Early in-frame STOP codon
Bo7 - 20670 20994 -- -- Disrupted frame
Bo8 + 21318 21521 -- -- overlapping with late 1.7 kb RNA
ORF 16 + 22967 23647 ORF 16 -- BORFB2; v-Bcl-2 protein
ORF 17 - 23710 25260 ORF 17 UL 26 capsid protein
ORF 18 + 25259 26077 ORF 18 --  
ORF 19 - 26029 27705 ORF 19 UL 25 tegument protein
ORF 20 - 27407 28219 ORF 20 UL 24  
ORF 21 + 28203 29540 ORF 21 UL 23 thymidine kinase
ORF 22 + 29551 31674 ORF 22 UL 22 glycoprotein H
ORF 23 - 31671 32873 ORF 23 --  
ORF 24 - 32851 35109 ORF 24 --  
ORF 25 + 35099 39220 ORF 25 UL 19 major capsid protein
ORF 26 + 39256 40170 ORF 26 UL 18 capsid protein
ORF 27 + 40184 40829 ORF 27 --  
Bo9 + 40831 41130 -- --  
ORF 29 - 41154 46328 ORF 29 UL 15 cleavage/packaging protein
ORF 30 + 42306 42548 ORF 30 --  
ORF 31 + 42482 43123 ORF 31 --  
ORF 32 + 43069 44439 ORF 32 UL 17 viral DNA cleavage/packaging protein
ORF 33 + 44432 45430 ORF 33 UL 16  
ORF 34 + 46327 47313 ORF 34 --  
ORF 35 + 47285 47758 ORF 35 --  
ORF 36 + 47787 48950 ORF 36 UL 13 kinase
ORF 37 + 48958 50427 ORF 37 UL 12 alkaline exonuclease
ORF 38 + 50379 50585 ORF 38 --  
ORF 39 - 50652 51761 ORF 39 UL 10 glycoprotein M
ORF 40 + 51877 53247 ORF 40 UL 8 helicase-primase complex component
ORF 41 + 53360 53881 ORF 41 -- helicase-primase complex component
ORF 42 - 53873 54748 ORF 42 UL 7  
ORF 43 - 54525 56375 ORF 43 UL 6 capsid protein
ORF 44 + 56323 58701 ORF 44 UL 5 helicase
ORF 45 - 58805 59530 ORF 45 --  
ORF 46 - 59530 60291 ORF 46 UL 2 uracil-DNA-glycosidase
ORF 47 - 60309 60731 ORF 47 -- glycoprotein L
ORF 48 - 60838 62382 ORF 48 --  
ORF 50 + 62586 65179 ORF 50 -- immediate early transcript 2; R transactivator protein
ORF 49 - 62600 63499 ORF 49 --  
Bo10 + 65696 66595 -- UL 54 glycoprotein gp80
ORF 52 - 66621 67007 ORF 52 --  
ORF 53 - 67073 67345 ORF 53 --  
ORF 54 + 67414 68262 ORF 54 UL 50 dUTPase
ORF 55 - 68321 68923 ORF 55 --  
ORF 56 + 68887 71418 ORF 56 UL 52 DNA replication protein
ORF 57 + 71512 72870 ORF 57 -- possible post-transcriptional transactivator
ORF 58 - 73294 74346 ORF 58 --  
ORF 59 - 74360 75535 ORF 59 -- DNA replication protein
ORF 60 - 75688 76605 ORF 60 UL 40 ribonucleotide reductase small subunit
ORF 61 - 76639 79020 ORF 61 UL 39 ribonucleotide reductase large subunit
ORF 62 - 79002 80021 ORF 62 UL 38 assembly/DNA maturation protein
ORF 63 + 79978 82797 ORF 63 -- tegument protein
ORF 64 + 82812 90488 ORF 64 UL 36 tegument protein
ORF 65 - 90504 90896 ORF 65 -- capsid protein
ORF 66 - 90893 92167 ORF 66 --  
ORF 67 - 92107 92877 ORF 67 UL 34 tegument protein
ORF 67.5 - 92881 93144 ORF 67.5 UL 33 Disrupted (late) methionine
ORF 68 + 93155 94504 ORF 68 UL 32 probable glycoprotein
ORF 69 + 94512 95405 ORF 69 UL 31  
Bo11 - 96158 96703 -- --  
Bo12 + 97442 97684 -- -- Early in-frame STOP codon
ORF 71 - 98328 98876 K13/ORF 71 -- BORFE2; v-FLIP
Bo13 + 98838 98983 -- -- Disrupted frame
ORF 73 - 99022 99783 ORF 73 -- BORFE3, LANA homologous
ORF 75 - 100274 103606 ORF 75 -- Disrupted (late) methionine; tegument protein/v-FGAM-synthetase
Bo14 - 104273 104785 -- --  
Bo15 - 105724 106038 -- --  
Bo16 + 106225 106494 -- --  
Bo17 + 106681 108003 -- -- viral beta-1,6-N-acetylglucosaminyltransferase
  1. a Positions of the respective ORFs of BoHV-4 on the LUR sequence. These are given from the first nucleotide of the start codon ATG to the last nucleotide of the stop codon.
  2. b Correspondance to HHV-8 genes is according to Zimmermann (2001).
  3. c Correspondance to HHV-1 genes was based on the presence of conserved domain with a BoHV-4 gene. Genes containing evolutionary conserved domains are highlighted in bold italic. The genes conserved in Herpesviridae are highlighted in bold (from Fu, 2008).