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Table 1 Mutations observed in HCV resistant to ribavirin

From: Selection of hepatitis C virus resistant to ribavirin

Nucleotide position* Nucleotide in J6/JFH1 Nucleotide in HCV-RR1 Nucleotide in HCV-RR2 Protein Amino-acid position*& Amino-acid in J6/JFH1 Amino-acid in HCV-RR1 Amino-acid in HCV-RR2
367 A C C core 9 R S S
376 A G G      
572 A G G   78 K E E
581 T C C   81 Y H H
773 G A A   145 G S S
901 C T T      
1021# C T T E1     
1691 G A A E2 451 G R R
1855 T C C      
1996 C C T      
2492 G A A   718 V I I
2667^ T C C P7 776 F S S
2803 G G A NS2     
3050 T C C   904 Y H H
3369 T G G   1010 L R R
3520 C C T NS3     
3691 C T T      
4937 G G A   1533 D D N
5143 C T T      
5473 G G A NS4a     
5686 G G A NS4b     
5704 C C T      
5753 T C C      
6583 C T T NS5a     
7216 C T T      
7320 C T T   2327 P L L
7441 G A A      
7573 T C C      
7652 A G G   2438 T A A
7710 G A A NS5b 2457 S N N
7996 C T T      
8065 A G G      
8188 C C T      
8286 C C T   2649 A A V
8359 A G G      
8911 T T C      
8971 C C T      
9018 T T C   2893 V V A
9082 T C C      
  1. * nomenclature is according to the JFH1 sequence, accession number AB047639.
  2. &Only amino-acids where a substitution in HCV-RR viruses was found are indicated.
  3. # Position 1021 is a mix of C and T in HCV-RR1 and HCV-RR2.
  4. ^ T2667C was also found in J6/JFH1 viruses that were passed without ribavirin (unpublished results).