Skip to main content

Table 1 Mutations observed in HCV resistant to ribavirin

From: Selection of hepatitis C virus resistant to ribavirin

Nucleotide position*

Nucleotide in J6/JFH1

Nucleotide in HCV-RR1

Nucleotide in HCV-RR2

Protein

Amino-acid position*&

Amino-acid in J6/JFH1

Amino-acid in HCV-RR1

Amino-acid in HCV-RR2

367

A

C

C

core

9

R

S

S

376

A

G

G

     

572

A

G

G

 

78

K

E

E

581

T

C

C

 

81

Y

H

H

773

G

A

A

 

145

G

S

S

901

C

T

T

     

1021#

C

T

T

E1

    

1691

G

A

A

E2

451

G

R

R

1855

T

C

C

     

1996

C

C

T

     

2492

G

A

A

 

718

V

I

I

2667^

T

C

C

P7

776

F

S

S

2803

G

G

A

NS2

    

3050

T

C

C

 

904

Y

H

H

3369

T

G

G

 

1010

L

R

R

3520

C

C

T

NS3

    

3691

C

T

T

     

4937

G

G

A

 

1533

D

D

N

5143

C

T

T

     

5473

G

G

A

NS4a

    

5686

G

G

A

NS4b

    

5704

C

C

T

     

5753

T

C

C

     

6583

C

T

T

NS5a

    

7216

C

T

T

     

7320

C

T

T

 

2327

P

L

L

7441

G

A

A

     

7573

T

C

C

     

7652

A

G

G

 

2438

T

A

A

7710

G

A

A

NS5b

2457

S

N

N

7996

C

T

T

     

8065

A

G

G

     

8188

C

C

T

     

8286

C

C

T

 

2649

A

A

V

8359

A

G

G

     

8911

T

T

C

     

8971

C

C

T

     

9018

T

T

C

 

2893

V

V

A

9082

T

C

C

     
  1. * nomenclature is according to the JFH1 sequence, accession number AB047639.
  2. &Only amino-acids where a substitution in HCV-RR viruses was found are indicated.
  3. # Position 1021 is a mix of C and T in HCV-RR1 and HCV-RR2.
  4. ^ T2667C was also found in J6/JFH1 viruses that were passed without ribavirin (unpublished results).
Back to article page

Virology Journal

ISSN: 1743-422X