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Table 3 Serum cytokine levels in mice inoculated with DENV-1 isolates from patients with DF, DHF, and DSS, respectively, and independent of inoculated virus concentration.

From: Phenotypic characterization of patient dengue virus isolates in BALB/c mice differentiates dengue fever and dengue hemorrhagic fever from dengue shock syndrome

Day p.i. Cytokine DF DHF DSS Mock
3 IFNγ 3.10 3.24 2.08 0.09
  IL-1β 3.15 0.00 0.00 0.00
  IL-2 1.46 2.00 1.05 0.00
  IL-6 1.48 1.65 2.69 3.22
  IL-10 4.20 3.13 0.00 0.00
  IL-13 88.83 73.12 80.23 98.84
  MCP-1 71.58 34.25 21.45 0.00
  RANTES 35.11 13.17 15.93 9.76
  TNFα 6.44 3.97 3.78 0.00
6 IFNγ 2.53 1.65 1.92 0.00
  IL-1β 3.15 0.00 0.00 0.00
  IL-2 1.46 1.44 2.21 2.21
  IL-6 0.36 0.77 3.10 2.69
  IL-10 2.05 0.00 0.00 0.00
  IL-13 70.84 62.33 51.19 121.60
  MCP-1 22.12 14.54 3.37 0.00
  RANTES 20.47 14.16 24.46 10.43
  TNFα 2.45 2.15 0.00 0.00
15 IFNγ 1.24 1.28 1.70 0.87
  IL-1β 0.00 0.00 0.00 0.00
  IL-2 2.20 1.19 5.61 0.00
  IL-6 0.18 1.88 1.65 0.03
  IL-10 1.03 0.00 0.00 0.00
  IL-13 67.20 91.70 84.96 75.57
  MCP-1 21.53 14.54 3.37 0.00
  RANTES 27.68 17.22 20.75 15.02
  TNFα 1.73 0.00 1.48 0.00
  1. The cytokines were measured in pg/mL.