Table 3 Serum cytokine levels in mice inoculated with DENV-1 isolates from patients with DF, DHF, and DSS, respectively, and independent of inoculated virus concentration.
Day p.i. | Cytokine | DF | DHF | DSS | Mock |
|---|---|---|---|---|---|
3 | IFNγ | 3.10 | 3.24 | 2.08 | 0.09 |
IL-1β | 3.15 | 0.00 | 0.00 | 0.00 | |
IL-2 | 1.46 | 2.00 | 1.05 | 0.00 | |
IL-6 | 1.48 | 1.65 | 2.69 | 3.22 | |
IL-10 | 4.20 | 3.13 | 0.00 | 0.00 | |
IL-13 | 88.83 | 73.12 | 80.23 | 98.84 | |
MCP-1 | 71.58 | 34.25 | 21.45 | 0.00 | |
RANTES | 35.11 | 13.17 | 15.93 | 9.76 | |
TNFα | 6.44 | 3.97 | 3.78 | 0.00 | |
6 | IFNγ | 2.53 | 1.65 | 1.92 | 0.00 |
IL-1β | 3.15 | 0.00 | 0.00 | 0.00 | |
IL-2 | 1.46 | 1.44 | 2.21 | 2.21 | |
IL-6 | 0.36 | 0.77 | 3.10 | 2.69 | |
IL-10 | 2.05 | 0.00 | 0.00 | 0.00 | |
IL-13 | 70.84 | 62.33 | 51.19 | 121.60 | |
MCP-1 | 22.12 | 14.54 | 3.37 | 0.00 | |
RANTES | 20.47 | 14.16 | 24.46 | 10.43 | |
TNFα | 2.45 | 2.15 | 0.00 | 0.00 | |
15 | IFNγ | 1.24 | 1.28 | 1.70 | 0.87 |
IL-1β | 0.00 | 0.00 | 0.00 | 0.00 | |
IL-2 | 2.20 | 1.19 | 5.61 | 0.00 | |
IL-6 | 0.18 | 1.88 | 1.65 | 0.03 | |
IL-10 | 1.03 | 0.00 | 0.00 | 0.00 | |
IL-13 | 67.20 | 91.70 | 84.96 | 75.57 | |
MCP-1 | 21.53 | 14.54 | 3.37 | 0.00 | |
RANTES | 27.68 | 17.22 | 20.75 | 15.02 | |
TNFα | 1.73 | 0.00 | 1.48 | 0.00 |