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Table 1 Viral RNA was found in various organs depending on inoculated DENV-1 isolate (DF, DHF, or DSS), virus concentration in inoculum, and time-point p.i. In total 54.3% of the DENV-1 infected mice had detectable levels of viral RNA.

From: Phenotypic characterization of patient dengue virus isolates in BALB/c mice differentiates dengue fever and dengue hemorrhagic fever from dengue shock syndrome

DENV isolate DF DHF DSS
Titer (PFU/mL)* 1.5 × 104 1.5 × 105 1.5 × 106 1.5 × 104 1.5 × 105 1.5 × 106 1.5 × 104 1.5 × 105 1.5 × 106
Day (p.i.)** 3 6 15 3 6 15 3 6 15 3 6 15 3 6 15 3 6 15 3 6 15 3 6 15 3 6 15
Heart - - - - - - - - - - - - - - - - - - - - - - - - - - -
Lungs - - - 2 3 - 2 3 1 - - - - 2 - 2 2 1 - - - - 3 1 1 1 1
Spleen 1 - - - - - 2 - - 1 - - - - 2 2 1 - - 1 - - 1 1 2 - -
Brain - - - - - - 1 - - 1 1 - - - - - 3 - - 1 2 1 3 2 - 2 -
Liver - - - - - - - - - - - - 1 1 - 2 - - - - - - - - - - -
Kidneys - - - - - - - - - - - - - - - - - - - 1 - - - - - - -
Infected mice 1 - - 2 3 - 3 3 1 2 1 - 1 2 2 3 3 1 - 3 2 1 3 3 2 2 1
Infected mice per titer 1 5 7 3 5 7 4 7 5
Infected mice per day p.i. 6 6 1 6 6 3 3 7 6
Σ infected mice per virus isolate 13 15 16
% infected mice per virus isolate 48.2% 55.6% 59.3%
  1. * Titer of inoculum was significant (p = 0.012).
  2. ** Time-point post-infection was significant (p = 0.014).