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Table 1 Viral RNA was found in various organs depending on inoculated DENV-1 isolate (DF, DHF, or DSS), virus concentration in inoculum, and time-point p.i. In total 54.3% of the DENV-1 infected mice had detectable levels of viral RNA.

From: Phenotypic characterization of patient dengue virus isolates in BALB/c mice differentiates dengue fever and dengue hemorrhagic fever from dengue shock syndrome

DENV isolate

DF

DHF

DSS

Titer (PFU/mL)*

1.5 × 104

1.5 × 105

1.5 × 106

1.5 × 104

1.5 × 105

1.5 × 106

1.5 × 104

1.5 × 105

1.5 × 106

Day (p.i.)**

3

6

15

3

6

15

3

6

15

3

6

15

3

6

15

3

6

15

3

6

15

3

6

15

3

6

15

Heart

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Lungs

-

-

-

2

3

-

2

3

1

-

-

-

-

2

-

2

2

1

-

-

-

-

3

1

1

1

1

Spleen

1

-

-

-

-

-

2

-

-

1

-

-

-

-

2

2

1

-

-

1

-

-

1

1

2

-

-

Brain

-

-

-

-

-

-

1

-

-

1

1

-

-

-

-

-

3

-

-

1

2

1

3

2

-

2

-

Liver

-

-

-

-

-

-

-

-

-

-

-

-

1

1

-

2

-

-

-

-

-

-

-

-

-

-

-

Kidneys

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

Infected mice

1

-

-

2

3

-

3

3

1

2

1

-

1

2

2

3

3

1

-

3

2

1

3

3

2

2

1

Infected mice per titer

1

5

7

3

5

7

4

7

5

Infected mice per day p.i.

6

6

1

6

6

3

3

7

6

Σ infected mice per virus isolate

13

15

16

% infected mice per virus isolate

48.2%

55.6%

59.3%

  1. * Titer of inoculum was significant (p = 0.012).
  2. ** Time-point post-infection was significant (p = 0.014).
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Virology Journal

ISSN: 1743-422X