Detection of HIV-1 dual infections in highly exposed treated patients

Table 2 Evolution of antiretroviral resistance mutations in HIV-1 individuals with dual infections

Case	Time points	Primary subtype		Secondary subtype
		Prot	RT	Prot	RT
C1		B subtype		BF recombinant (not CRF12)
	S1	NONE	M41L/M184V/Y188L/L210W/T215Y²¹ V106I, H221Y and D67N ^(A)	NONE	NONE
	S2	L10I/I15V/M46I/L63P/I84V/I85V/L90M¹² M36I and F53L/A71T ^(A)	M41L/D67N/L210W/T215Y¹²	NON DETECTED
C2		CRF12_BF		B subtype
		NONE	NONE	I84V/L90M	M41L/K70E/L210W/T215Y
C3		B subtype		CRF12_BF
		NONE	K103N¹	NONE	NONE
C4		CRF12_BF		B subtype
	S1	I47V¹	NONE	NONE	NONE
	S2	NONE	K70R¹	NON DETECTED
C5		CRF12_BF		BF recombinant (not CRF12)
	S1	NONE	Y181C/H221Y²	NON DETECTED
	S2	NONE	Y181C¹	NONE	NONE

A mean of sixteen sequences and/or clones per sample were analyzed with Stanford software. Resistance mutations separeted by bars indicate combination of mutations in the sequences. The number indicated by superscript shows the number of sequences or clones with the corresponding mutation or combination of mutations.
(A) Each mutation in different sequences and carrying the combination of mutations indicated.

ISSN: 1743-422X