Table 1 Demographic and biochemical characteristics of patients in initial and validation cohorts
From: Association of laboratory parameters with viral factors in patients with hepatitis C
Variables | Initial Cohort 2006-08 (n = 3160)> | Validation Cohort 1 2008-09 (n = 1364) | Validation Cohort 2 2009-10 (n = 1524) | Overall 2006-10 (n = 6048) |
|---|---|---|---|---|
Gender | ||||
   Male | 1515 (47.9%) | 718 (52.6%) | 833 (54.7%) | 3066 (50.7%) |
   Female | 1645 (52.1%) | 646 (47.4%) | 691 (45.3%) | 2982 (49.3%) |
Age | ||||
   Mean | 37.08 ± 10.33 | 37.15 ± 11.65 | 38.29 ± 11.361 | 37.40 ± 10.91 |
   Range | 6-75 | 12-71 | 10-75 | 6-75 |
Age Group | ||||
   <40 | 2119 (67.1%) | 832 (61.0%) | 864 (56.7%) | 3815 (63.1%) |
   >40 | 1041 (32.9%) | 532 (39.0%) | 660 (43.3%) | 2233 (36.9%) |
Biochemical Markers (All values in median (Range) | ||||
Viral titer (IU/mL) | 1.0 × 107 (1340-8.5 × 108) | 3.20 × 105 (10000-4.0 × 108) | 1.8 × 107 (10000-4.0 × 108) | 2.0 × 106 (1340-8.5 × 108) |
Hb level(mg/dl) | 13.1 (9.8-16.7) | 14.0 (13.1-16.9) | 11.4 (8.8-15.6) | 13.1 (8.8-16.9) |
Bilirubin (mg/dl) | 0.80 (0.1-1.3) | 0.80 (0.3-1.2) | 0.80 (0.1-1.9) | 0.80 (0.1-1.9) |
ALP (IU/mL) | 185.0 (85-421) | 165.0 (30-396) | 165.5 (30-392) | 176.0 (24-421) |
ALT (IU/mL) | 58.0 (14-238) | 57.0 (13-311) | 59.0 (11-308) | 58.0 (11-311) |
AST (IU/mL) | 56.0 (13-230) | 55.0 (16-218) | 57.0 (19-236) | 56 (13-236) |
AAR | 0.96 ± (0.155.75) | 0.96 (0.07-7.50) | 0.98 (0.06-9.09) | 0.96 (0.06-9.09) |
Genotypes | ||||
   1 | 365 (11.6%) | 206 (15.1%) | 231 (15.2%) | 802 (13.3%) |
   2 | 31 (1.0%) | 27 (2.0%) | 55 (3.6%) | 113 (1.9%) |
   3 | 2359 (74.7%) | 934 (68.5%) | 994 (65.2%) | 4287 (70.9%) |
   4 | 224 (7.1%) | 89 (6.5%) | 133 (8.7%) | 446 (7.4%) |
   5 | 28 (0.9%) | 0 | 3 (0.2%) | 31 (0.5%) |
   6 | 19 (0.6%) | 4 (0.3%) | 3 (0.2%) | 26 (0.4%) |
   Mix | 96 (3.0%) | 46 (3.4%) | 55 (3.6%) | 197 (3.3%) |
   Undefined | 38 (1.2%) | 58 (4.3%) | 50 (3.3%) | 146 (2.4%) |