Table 5 Analysis of HCV infection by in situ hybridization in chronic HCV-infected individuals

Co-infected

5'UTR-core-E1

42/63 liver; Some only hepatocytes, some (portal) monocytes/sinusoidal/biliary

[55]

End-stage liver disease

5'UTR-core-E1

10/20 perihepatic lymph nodes

[41]

HCC

5'UTR, core, NS4B

4/9 HCC hepatocytes; 7/10 Non-HCC

[199]

HCC

5'UTR

Hepatocytes positive, some mononuclear, no biliary or mesenchymal

[200]

LT

5'UTR

2/11 LT patients, 2/11 PBMC, 3/3 mitogen stimulated PBMC

[40]

MC

5'UTR, core

12/12 hepatocytes

[201]

NHL, MC

5'UTR

Ductal and acinar salivary epithelial cells

[42]

Occult

5'UTR

11/18 PBMC

[36]

Oral lichen planus

5'UTR

14/19 oral epithelia

[44]

Sjogren's syndrome or Chronic sialadenitis

5'UTR

8/8 salivary gland

[43]

35% of genome used

Hepatocytes not infected-macrophages or lymphocytes; No - strand detected

[202]

SVR

5'UTR

15/19 Liver

[57]

Chronic

core-E1

8 of 8 hepatocytes

[56]

Chronic

core-E1

Quantitative image analysis; hepatocytes, some Kuppfer; +/- ratio 3-20

[147]

Chronic

7 regions

Some hepatocytes positive for negative strands

[203]

Chronic

5'UTR

24/28 liver negative strand; 14/17 PBMC negative strand;

[37]

Chronic

5'UTR

9/20 liver-perinuclear in hepatocytes; mononuclear cells had only positive strands

[204]

Chronic

5'UTR

4 of 11, all HIV co-infected-hepatocytes and mononuclear cells

[205]

Chronic

NS5

4/10 H nuclei; 6/10 H cytoplasm; 4/10 M; 0/10 Bile duct epithelial

[54]

Chronic

5'UTR

FISH, positive strands only: 15-70% of liver cells positive, 0.1 to 4% PBMC positive

[39]

Chronic

5'UTR, core

4/5 liver, 5/20 PBMC, 0/20 BM

[38]

Chronic

5'UTR, core, NS4B

4/10 hepatocytes; 2/4 some lymphocytes

[206]

Chronic

5'UTR

17/19 hepatocytes

[34]