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Figure 5 | Virology Journal

Figure 5

From: Single amino acid change in gp41 region of HIV-1 alters bystander apoptosis and CD4 decline in humanized mice

Figure 5

Immune activation is seen in the CD8+ T cells from both WT and V38E infected mice. HLADR expression on CD8 (A) and CD4 (B) cells as well as PD1 expression on CD8 (C) and CD4 cells (D) were determined in PBMC obtained from mice at different time points postinfection. A representative histogram at 8 weeks (top) and serial cumulative data from 3 mice (bottom) is shown. (E) Expression of immune activation markers HLADR and PD-1 on splenocytes isolated at 8 weeks postinfection. Each symbol represents an individual mouse.

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