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Figure 4 | Virology Journal

Figure 4

From: Single amino acid change in gp41 region of HIV-1 alters bystander apoptosis and CD4 decline in humanized mice

Figure 4

V38E mutant replicates in Mice without reverting to WT. (A) Viruses were recovered from mice sacrificed at the 8 weeks post infection by coculturing PHA and IL-2-activated PBMCs with SupT1 cells. Supernatants were harvested at different time points and RT activity determined. (B) Photomicrographs of cultures in (A) on day 10 is shown. Magnification = 10X. (C) Sequence analysis of proviral gp41 from WT and V38E infected mice.

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Virology Journal

ISSN: 1743-422X