A new permanent cell line derived from the bank vole (Myodes glareolus) as cell culture model for zoonotic viruses

Table 1 Viruses used for the infectability analysis of the established bank vole cell line

Family	Genus	Group, virus	Strain	Original cell line	Pathogenic for humans	Role of rodents	Pathogenic for other vertebrates
Rhabdoviridae	Vesiculovirus	Vesicular stomatitis virus	India	Vero B4	+	neurotrop; deer mouse may transmit VSV ¹	+, cattle, pigs
Poxviridae	Orthopoxvirus	Vaccinia virus	Munich 1	Ma104	+	host ²	+, cattle
Poxviridae	Orthopoxvirus	Cowpox virus	81/01	Ma104	+	host ³	+, broad host range
Togaviridae	Alphavirus	Sindbis virus	Australia C377	Vero B4	+	neuropathogenic in suckling lab mice ⁴	birds
Togaviridae	Alphavirus	Pixuna virus	BeAr 35645	Vero B4	+	neuropathogenic for lab rats and mice ⁵	+, horses
Bunyaviridae	Orthobunyavirus	Inkoovirus	TN-98-5085*	Vero B4	+	pathogenic for lab mice ⁶	unknown°
Bunyaviridae	Hantavirus	Puumalavirus	Vranica	Vero E6	+	M. glareolus serve as PUUV reservoir ⁷	-
Flaviviridae	Flavivirus	Usutu virus	0679/2006	Vero B4	+	neuropathogenic for suckling mice ⁸	+, birds
Bornaviridae	Bornavirus	Borna disease virus	BDV H24 adapted to Lewis rats	rabbit embryonic brain cells	(+)	neuropathogenic for Lewis rats ⁹ and white mice ¹⁰	+, horses, sheep, rabbits

* Pfeffer unpublished data; ^° high seroprevalences found in large animals
References: ¹ [15]; ² [16, 17]; ³ for review see [7]; ⁴ [18]; ⁵ [19]; ⁶ [20, 21]; ⁷ [22]; ⁸ [23]; ⁹ [24]; ¹⁰ [25]

ISSN: 1743-422X