Figure 3
From: Vaccination with dengue virus-like particles induces humoral and cellular immune responses in mice
Virus specific IgG were enhanced by DENV VLPs or virions. BALB/c mice were intraperitoneally immunized with 100 μg monovalent DENV VLPs or virions (A-D), or tetravalent VLPs or virions (E 25 μg of each serotype) for three times at two-week intervals. At day 14, 28, 42, sera were collected and ELISA was used to test for rEIII specific IgG. Data were expressed as mean titer with a standard deviation (SD) bar. *indicates statistical significance (P < 0.05).