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Figure 4 | Virology Journal

Figure 4

From: A STAT-1 knockout mouse model for Machupo virus pathogenesis

Figure 4

Pathology. Panels on the left of the figure (A, C, E and G) show representative photomicrographs of H&E stained sections of spleen, pancreas, thymus, and liver, respectively, removed from uninfected mice at day 0. Panel B shows the representative disruption of the splenic white pulp architecture at day 7 post-infection, with marked lymphocyte death (example in enlarged inset). Panel D demonstrates pancreatitis, which was observed in all 4 animals at day 7 post infection. Panel F is an example of the complete thymic cortical atrophy observed in all day 7 post-infection mice. Panel H is a representative sample of day 7 liver, demonstrating mild to moderate areas of inflammation and necrosis (left arrow) and regions of hepatocellular degeneration and cell death (right arrow) (Panels A, B, G and H at 200x magnification, scale bar is 50 microns; Panels C, D, E and F, scale bar is 10 microns).

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