Figure 1
From: A STAT-1 knockout mouse model for Machupo virus pathogenesis
Wild-type MACV is lethal in STAT-1 knockout mice. A) STAT-1 knockout mice were infected with 1000 pfu MACV via the intraperitoneal (n = 6), subcutaneous (n = 6), or intranasal route (n = 4) and monitored for survival. Intraperitoneal infection was used for subsequent studies. B) Tissue samples were harvested at days 3, 5, and 7 after MACV infection and evaluated for viral load (plasma, n = 7-8; spleen, liver, lung, kidney n = 4).