Figure 9From: A novel fusogenic herpes simplex virus for oncolytic virotherapy of squamous cell carcinomaHistopathological changes and virus gene expression in oral SCC xenografts in nude mice. Oral SCC xenografts in nude mice were given 1 × 106 PFUs of HF or RH2. After 3, 5, 7, and 14 days, they were subjected to immunohistochemical staining and the mean size (μm2) of HSV-1 antigen-positive multinucleated cells in the sections was determined. Data are means ± SD of three determinations. At 14 days, a significantly difference was observed between HF and RH2 (*P < 0.05).Back to article page