Figure 7
From: A novel fusogenic herpes simplex virus for oncolytic virotherapy of squamous cell carcinoma
Histopathological changes and virus gene expression in oral SCC xenografts in nude mice. Oral SCC xenografts in nude mice were given 1 × 106 PFUs of R849 (a, b), HF (c, d), or RH2 (e, f). Tumors with skin were removed 3 days after infection and subjected to immunohistochemical staining using antibody against HSV-1. Arrows indicate rounded cells (b) and multinucleated cells (d, f).