Schematic representation of the organization of dengue virus polyprotein. Representation of DV protein structure illustrating the predicted orientation across the endoplasmic reticulum (ER). Cylinders represent transmembrane (T) helices. prM, membrane protein precursor; E, envelope protein; NS1, non-structural protein. The sequences of the E protein T1 and M protein T1 are shown. Underlined residues indicate the amino acids targeted for deletion. The TM domain of the capsid protein is cleaved during processing and is not present in the membrane of the assembled virus.