Figure 3

Percentage of PD-1 positive cells on CD127^-CD25^-, CD127⁺CD25^lo/- and CD127^loCD25^hi FoxP3⁺ CD4+ T cell subsets. (A): Representative dot plot analysis showing the expression of PD-1 on these three subsets. PD-1 expressions on these T cell subsets were significantly higher in chronic HCV-infected patients (half black symbols) than in healthy controls (open symbols) presented by both of percentage (B) and MFI (C). PD-1 expression on Treg cells (CD127^loCD25^hi FoxP3⁺) was lower than on paired CD127^-CD25^- and CD127⁺CD25^lo/- subsets. ^▵indicated that Wilcoxon match pairs test. *P < 0.05; **P < 0.01; ***P < 0.001.