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Table 2 The influence of various cytokine on FMDV DNA vaccine

From: Research in advance for FMD Novel Vaccines

Cytokine Effective on FMDV DNA vaccine
IL-1/IL-2 Advanced the humoral immune response induced by FMD inactivated vaccines. [38, 39]
IL-6 Advanced the cellular immune response induced by FMD DNA vaccines, Promoting the maturation and immune function of dendritic cells [40]
IL-9 Increased a robust antigen specific cytotoxicity T lymphocyte response [41]
IL-15 Enhanced the cellular and mucosal immune response and the level of IFN-γinduced by FMD DNA vaccines [42]
IL-18 Increased the immunogenicity of DNA vaccines coding P12A and 3C of FMDV [43]
CSF Enhanced immune responses against a plasmid DNA vaccine encoding FMDV empty capid [44]
INF-α/β Advanced the cellular immune response induced by FMD DNA vaccines, Promoted the maturation and immune function of dendritic cells
INF-γ Enhanced both humoral and cell-mediated immune responses[12]