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Figure 4 | Virology Journal

Figure 4

From: Herpes simplex virus induces the marked up-regulation of the zinc finger transcriptional factor INSM1, which modulates the expression and localization of the immediate early protein ICP0

Figure 4

Expression and localization of ICP0 in INSM1-expressing cells. HEp-2 (A and D), Vero (B), and HaCaT (C) cells were transfected with plasmids encoding Myc-tagged full-length INSM1 (INSM1-FL) and deletion mutants (N and C). At 20-24 h after transfection, cells were infected with HSV-1(F) (MOI = 3), fixed at 4 h (A, B and C) or 18 h (D) after infection, and reacted with anti-Myc and anti-ICP0 antibodies as described in Methods.

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