TY - JOUR AU - Kamakura, Maki AU - Goshima, Fumi AU - Luo, Chenhong AU - Kimura, Hiroshi AU - Nishiyama, Yukihiro PY - 2011 DA - 2011/05/25 TI - Herpes simplex virus induces the marked up-regulation of the zinc finger transcriptional factor INSM1, which modulates the expression and localization of the immediate early protein ICP0 JO - Virology Journal SP - 257 VL - 8 IS - 1 AB - Herpes simplex viruses (HSVs) rapidly shut off macromolecular synthesis in host cells. In contrast, global microarray analyses have shown that HSV infection markedly up-regulates a number of host cell genes that may play important roles in HSV-host cell interactions. To understand the regulatory mechanisms involved, we initiated studies focusing on the zinc finger transcription factor insulinoma-associated 1 (INSM1), a host cell protein markedly up-regulated by HSV infection. SN - 1743-422X UR - https://doi.org/10.1186/1743-422X-8-257 DO - 10.1186/1743-422X-8-257 ID - Kamakura2011 ER -