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Table 3 Amino acid composition (polar and non polar amino acids) in HVR1 of E2 protein

From: Characterization of Hepatitis C Virus genotype 3a Hypervariable region 1 in patients achieved rapid virological response to alpha interferon and Ribavirin Combination therapy

HVR 1

Polar a.a composition

Non polar a.a composition

 

+ve charged (basic)

- ve charged(acidic)

Neutral

 

RR group (15 variants)

Lys(K)3.94

Asp(D).23

Ser(S)18.29

Ala(A)9.95

 

His(H)3.01

Glu(E)-

Thr(T)15.28

Val(V)5.56

 

Arg(R)3.94

 

Gln(Q)4.17

Leu(L)7.87

   

Cys(C)-

Ile(I)1.85

   

Asn(N)5.09

Gly(G)12.73

   

Tyr(Y)2.78

Trp(W)0.23

    

Phe(F)3.47

    

Pro(P)1.62

    

Met(M)-

Average

10.89

.23

45.61

43.28

BT group (14 variants)

Lys(K)3.21

Asp(D)2.22

Ser(S)11.60

Ala(A)11.36

 

His(H)3.70

Glu(E)-

Thr(T)10.62

Val(V)5.43

 

Arg(R)5.19

 

Gln(Q)6.67

Leu(L)6.42

   

Cys(C)-

Ile(I).25

   

Asn(N)2.72

Gly(G)18.52

   

Tyr(Y) 3.95

Trp(W)-

    

Phe(F)4.44

    

Pro(P)3.70

    

Met(M)-

Average

12.1

2.22

35.56

50.12

  1. Comparison of average composition of twenty amino acids between rapid responders and breakthrough responders. Average composition of polar and non polar amino acids in HVR1 of rapid responders (R.R) and breakthrough responders (B.T).
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Virology Journal

ISSN: 1743-422X