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Table 2 amino acids substitution in HVR1 of E2 protein (Breakthrough responders)

From: Characterization of Hepatitis C Virus genotype 3a Hypervariable region 1 in patients achieved rapid virological response to alpha interferon and Ribavirin Combination therapy

H

T

Y

T

T

G

G

T

A

A

R

N

T

K

G

L

A

G

L

F

Y

P

G

A

K

Q

K

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

21

22

23

24

25

26

27

S9

  

T9

S9

  

S9

  

R9

D9

V8

H5

 

L9

V9

G9

 

F12

S14

P9

 

A9

Q9

Q12

R9

G5

  

V5

T5

  

Q5

  

S5

H5

T5

K9

 

F5

T5

N5

 

S

 

A5

 

P5

K5

R2

N5

            

I1

      

L

       
  1. Amino acid substitution at each amino acid position analyzed from pre-treatment patient samples that belong to breakthrough responders (B.T). B.T group (2 samples and 14 clones) contains 9 conserved sites and 18 variable sites. Conserved sites are shown in bold and non-italic letters