Table 1 List of siRNAs used in this study

siS1

91 to 111

Sense 5'-AGAUUGUUGCCAGUACUAAdTdT-3'

Antisense 5'-UUAGUACUGGCAACAAUCUdTdG-3'

S Hazara segment JC280

[DQ076419.1]

siS2

1321 to 1341

Sense 5'-AGGCAGUCCUCAACUAUAAdTdT-3'

Antisense 5'-UUAUAGUUGAGGACUGCCUdTdT-3'

siS3

641 to 661

Sense 5'-CGAUGAUGCGCCAAAGAGAdTdT-3'

Antisense 5'-UCUCUUUGGCGCAUCAUCGdGdA-3'

siS4

881 to 901

Sense 5'-CAAAGACCAAGUCGACCAAdTdT-3'

Antisense 5'-UUGGUCGACUUGGUCUUUGdTdT-3'

siM1

3260 to 3280

Sense 5'-CAGUCAUGAUGGUGGUUUAdTdT-3'

Antisense 5'-UAAACCACCAUCAUGACUGdTdG-3'

M Hazara segment JC280

[DQ813514.1]

siM2

3929 to 3949

Sense 5'-CGAGCAUAAGGGUACAAUAdTdT-3'

Antisense 5'-UAUUGUACCCUUAUGCUCGdAdG-3'

siM3

1689 to 1709

Sense 5'-GAUGAAAGUUGCUCCUAUAdTdT-3'

Antisense 5'-UAUAGGAGCAACUUUCAUCdGdT-3'

siM4

2924 to 2944

Sense 5'-CAAAUACUUUGUCACCAAAdTdT-3'

Antisense 5'-UUUGGUGACAAAGUAUUUGdTdT-3'

siL1

10545 to 10565

Sense 5'-CGAGGAUAAUAUUGGCAAAdTdT-3'

Antisense 5'-UUUGCCAAUAUUAUCCUCGdTdG-3'

L Hazara segment JC280

[M86624.1]

siL2

9847 to 9867

Sense 5'-CGAGGAUAAUAUUGGCAAAdTdT-3'

Antisense 5'-UAAAGUGUUUAUUAUAACCdTdG-3'

siL3

1408 to 1428

Sense 5'-CAGAGAAAUUGCUGAUAUAdTdT-3'

Antisense 5'-UAUAUCAGCAAUUUCUCUGdTdG-3'

siL4

10323 to 10343

Sense 5'-CAGUGAUAAAGGUAAAGAAdTdT-3'

Antisense 5'-UUCUUUACCUUUAUCACUGdGdG-3'

Non targeting siRNA (siNT)

Sense 5'-UUCUCCGAACGUGUCACGUdTdT-3'

Antisense 5'-ACGUGACACGUUCGGAGAAdTdT-3'