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Table 3 Top 10 up-regulated pathways in C-33A cells expressing E2.

From: HPV16 E2 could act as down-regulator in cellular genes implicated in apoptosis, proliferation and cell differentiation

Cellular Pathway

No. genes altered

Wnt signaling pathway

15

Inflammation mediated by chemokine and cytokine signaling pathway

10

Angiogenesis

8

Integrin signalling pathway

8

Cadherin signaling pathway

8

B cell activation

8

Apoptosis signaling pathway

7

PDGF signaling pathway

7

EGF receptor signaling pathway

7

Oxidative stress Response

6

  1. Cellular Pathways with the greatest number of genes up-regulated by HPV16 E2 were selected as main pathways altered by E2. Ontological analysis was based on the algorithm used by PANTHER system (Protein ANalysis Through Evolutionary Relationships).