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Table 1 Highly up-regulated genes in C-33A cells by HPV16 E2 expression

From: HPV16 E2 could act as down-regulator in cellular genes implicated in apoptosis, proliferation and cell differentiation

Gene ID

Symbol

Name

Fold Change

NM_017839

LPCAT2

Lysophosphatidylcholine acyltransferase 2

5.3

NM_002071

GNAL

Guanine nucleotide binding protein (G protein)

4.9

NM_018667

SMPD3

Sphingomyelin phosphodiesterase 3

4.7

NM_004283

RAB3D

RAB3D, member RAS oncogene family

4.5

NM_006327

TIMM23

Translocase of inner mitochondrial membrane 23 homolog (yeast)

4.5

NM_017902

HIF1AN

Hypoxia inducible factor 1

4.2

NM_001421

ELF4

E74-like factor 4

3.9

NM_023919

TAS2R7

Taste receptor, type 2, member 7

3.9

NM_004289

NFE2L3

Nuclear factor (erythroid-derived 2)-like 3

3.9

NM_003630

PEX3

Peroxisomal biogenesis factor 3

3.8

NM_025087

CWH43

Cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)

3.8

NM_013417

IARS

Isoleucyl-tRNA synthetase

3.8

NM_012338

TSPAN12

Tetraspanin 12

3.7

NM_004131

GZMB

Granzyme B (granzyme 2)

3.7

NM_002427

MMP13

Matrix metallopeptidase 13 (collagenase 3)

3.6

NM_017849

TMEM127

Transmembrane protein 127

3.6

NM_003821

RIPK2

Receptor-interacting serine-threonine kinase 2

3.6

NM_003958

RNF8

Ring finger protein 8

3.5

NM_004224

GPR50

G protein-coupled receptor 50

3.5

NM_001244

TNFSF8

Tumor necrosis factor (ligand) superfamily, member 8

3.4

NM_020375

C12orf5

Chromosome 12 open reading frame 5

3.4

NM_004219

PTTG1

Pituitary tumor-transforming 1

3.4

NM_005925

MEP1B

Meprin A, beta

3.4

NM_024730

RERGL

RERG/RAS-like

3.3

NM_014942

ANKRD6

Ankyrin repeat domain 6

3.3

NM_032946

NXF5

Nuclear RNA export factor 5

3.3

NM_004528

MGST3

Microsomal glutathione S-transferase 3

3.3

NM_012280

FTSJ1

FtsJ homolog 1 (E. coli)

3.3

NM_001372

DNAH9

Dynein, axonemal, heavy chain 9

3.2

NM_013256

ZNF180

Zinc finger protein 180

3.2

NM_003569

STX7

Syntaxin 7

3.2

NM_018370

DRAM1

DNA-damage regulated autophagy modulator 1

3.2

NM_017817

RAB20

RAB20, member RAS oncogene family

3.2

NM_020377

CYSLTR2

Cysteinyl leukotriene receptor 2

3.2

NM_022087

GALNT11

N-acetylgalactosaminyltransferase 11

3.2

NM_004426

PHC1

Polyhomeotic homolog 1 (Drosophila)

3.2

NM_031857

PCDHA9

Protocadherin alpha 9

3.2

NM_019863

F8

Coagulation factor VIII, procoagulant component

3.1

NM_018840

C20orf24

Chromosome 20 open reading frame 24

3.1

NM_006243

PPP2R5A

Protein phosphatase 2, regulatory subunit B', alpha isoform

3.1

NM_017946

FKBP14

FK506 binding protein 14, 22 kDa

3.1

NM_025212

CXXC4

CXXC finger 4

3.1

NM_012214

MGAT4A

Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A

3.1

NM_012087

GTF3C5

General transcription factor IIIC, polypeptide 5, 63 kDa

3.1

NM_017952

PTCD3

Pentatricopeptide repeat domain 3

3.1

NM_005967

NAB2

NGFI-A binding protein 2 (EGR1 binding protein 2)

3.1

NM_016021

UBE2J1

Ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)

3.1

NM_014945

ABLIM3

Actin binding LIM protein family, member 3

3.1

NM_001006

RPS3A

Ribosomal protein S3A

3.1

NM_012200

B3GAT3

Beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)

3.1

  1. Fold Change refers to differences in Z score values compared to expression in non-infected cells, analysis was perform using genArise software. Changes in gene expression with a cut-off >3.1 was used and the p-value was calculated by Student's t-test.