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Table 3 The IC50 values of BmPCP against infection by primary HIV-1 isolates circulating in China

From: Inhibitory activity of 9-phenylcyclohepta[d]pyrimidinedione derivatives against different strains of HIV-1 as non-nucleoside reverse transcriptase inhibitors

   

BmPCP

NVP

HIV-1

subtype

Co-receptor

IC50 a(μM)

SIb

IC50 a(μM)

SIb

AH104

B'

X4/R5

0.59 ± 0.34

153

0.007 ± 0.003

29,143

AH259

B'

R5

0.32 ± 0.15

282

0.007 ± 0.001

29,143

AH968

B'

R5

0.44 ± 0.17

205

0.058 ± 0.060

3,517

XJ257

B'/C

R5

0.53 ± 0.07

170

0.211 ± 0.120

967

XJ0793

B'/C

R5

0.25 ± 0.03

361

0.079 ± 0.097

2,582

XJ6291

B'/C

R5

0.57 ± 0.02

158

0.186 ± 0.224

1,097

  1. a Compounds were tested in triplicate and the data are presented as means ± SD.
  2. b Selectivity index(SI) = CC50/IC50
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Virology Journal

ISSN: 1743-422X