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Table 3 The IC50 values of BmPCP against infection by primary HIV-1 isolates circulating in China

From: Inhibitory activity of 9-phenylcyclohepta[d]pyrimidinedione derivatives against different strains of HIV-1 as non-nucleoside reverse transcriptase inhibitors

    BmPCP NVP
HIV-1 subtype Co-receptor IC50 a(μM) SIb IC50 a(μM) SIb
AH104 B' X4/R5 0.59 ± 0.34 153 0.007 ± 0.003 29,143
AH259 B' R5 0.32 ± 0.15 282 0.007 ± 0.001 29,143
AH968 B' R5 0.44 ± 0.17 205 0.058 ± 0.060 3,517
XJ257 B'/C R5 0.53 ± 0.07 170 0.211 ± 0.120 967
XJ0793 B'/C R5 0.25 ± 0.03 361 0.079 ± 0.097 2,582
XJ6291 B'/C R5 0.57 ± 0.02 158 0.186 ± 0.224 1,097
  1. a Compounds were tested in triplicate and the data are presented as means ± SD.
  2. b Selectivity index(SI) = CC50/IC50