Skip to main content

Advertisement

Table 2 The inhibitory activity of BmPCP on infection in different cells

From: Inhibitory activity of 9-phenylcyclohepta[d]pyrimidinedione derivatives against different strains of HIV-1 as non-nucleoside reverse transcriptase inhibitors

   TZM-bl PBMCs MT4
Compounds HIV-1 strain IC50a (μM) SIb IC50 a (μM) SIb IC50 a(μM) SIb
BmPCP 1617-1 1.45 ± 0.21 62 1.76 ± 0.23 65 1.47 ± 0.43 128
  SF33 0.34 ± 0.09 266 1.72 ± 0.37 67 1.96 ± 0.58 84
NVP 1617-1 0.16 ± 0.10 - 0.57 ± 0.08 - 0.44 ± 0.12 -
  SF33 0.19 ± 0.02 - 0.69 ± 0.07 - 0.65 ± 0.23 -
  1. a Compounds were tested in triplicate and the data are presented as means ± SD.
  2. b Selectivity index(SI) = CC50/IC50