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Table 2 The inhibitory activity of BmPCP on infection in different cells

From: Inhibitory activity of 9-phenylcyclohepta[d]pyrimidinedione derivatives against different strains of HIV-1 as non-nucleoside reverse transcriptase inhibitors

  

TZM-bl

PBMCs

MT4

Compounds

HIV-1 strain

IC50a (μM)

SIb

IC50 a (μM)

SIb

IC50 a(μM)

SIb

BmPCP

1617-1

1.45 ± 0.21

62

1.76 ± 0.23

65

1.47 ± 0.43

128

 

SF33

0.34 ± 0.09

266

1.72 ± 0.37

67

1.96 ± 0.58

84

NVP

1617-1

0.16 ± 0.10

-

0.57 ± 0.08

-

0.44 ± 0.12

-

 

SF33

0.19 ± 0.02

-

0.69 ± 0.07

-

0.65 ± 0.23

-

  1. a Compounds were tested in triplicate and the data are presented as means ± SD.
  2. b Selectivity index(SI) = CC50/IC50