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Table 1 The inhibitory activity of PCPs on infection by HIV-1 SF33

From: Inhibitory activity of 9-phenylcyclohepta[d]pyrimidinedione derivatives against different strains of HIV-1 as non-nucleoside reverse transcriptase inhibitors

Compounds Virus/Cell CC50(μM) IC50(μM) SIa
BmPCP SF33/MT4 165.29 1.96 84
  SF33/TZM-bl 90.26 0.34 266
APCP SF33/MT4 62 28.6 2.17
  SF33/TZM-bl 50 1.3 38.46
BPCP SF33/MT4 132.25 114,7 1.15
  SF33/TZM-bl 180 9 20
EPCP SF33/MT4 29.28 7.5 3.9
  SF33/TZM-bl 22 1.6 13.75
  1. aSelectivity index(SI) = CC50/IC50