Figure 4
From: Oncolysis of malignant human melanoma tumors by Coxsackieviruses A13, A15 and A18
SK-Mel-28 tumors are responsive to intratumoral CVA13, CVA15 and CVA18 therapy in SCID mice. Severe combined immunodeficient (SCID) mice bearing preformed s.c. tumors (approximately 150 mm3) growing on the flanks after injection of 1 × 106 SK-Mel-28 cells, received an intratumoral injection with a single dose of CVA13, CVA15, CVA18 (105 TCID50) or PBS (n = 5 for each group). The average relative tumor sizes were measured externally with calipers and are expressed as the means of five treated mice ± S.E. * and ** indicate statistical significance of tumor volumes compared to the control, P < 0.05 and P < 0.01 respectively (One-way ANOVA).