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Table 2 Immunohistochemical findings from cynomolgus monkeys infected with Lassa virus

From: Pathogenesis of lassa fever in cynomolgus macaques

Animal No. Days PI Lymph nodes Spleen
   Mono Mac Dend End Mono Mac Dend End
Subj 1 7 + + ++ + + + ++ -
Subj 2 7 + + +++ + + + +++ -
Subj 3 7 + + ++ + + + ++ -
Subj 4 13 + + + ++ + + + ++
Subj 5 15 + + + ++ + + + ++
Subj 6 17 + + + ++ + + + ++
Animal No. Days PI Liver/Adrenal Brain
   Kup Hep Cort End Neur Glial Mac End
Subj 1 7 - + + - - - - +
Subj 2 7 ++ ++ ++ - - - + +
Subj 3 7 + + + - - - + -
Subj 4 13 ++ ++ +++ ++ - - ++ ++
Subj 5 15 ++ +++ +++ ++ - - ++ ++
Subj 6 17 ++ ++ +++ ++ - + ++ ++
  1. + indicates that LASV antigen-positive cells were rarely detected; + + indicates that LASV-positive cells were occasionally detected; + + + indicates that LASV-positive cells were frequently detected; and - indicates that no LASV-positive cells were detected.
  2. Mono = monocytes; Mac = macrophages; DC = dendritic cells; End = Endothelial cells; Kup = Kupffer cells; Hep = hepatocytes; Cort = adrenal cortical cells; Neur = Neurons.