Pathogenesis of lassa fever in cynomolgus macaques

Table 2 Immunohistochemical findings from cynomolgus monkeys infected with Lassa virus

Animal No.	Days PI	Lymph nodes				Spleen
		Mono	Mac	Dend	End	Mono	Mac	Dend	End
Subj 1	7	+	+	++	+	+	+	++	-
Subj 2	7	+	+	+++	+	+	+	+++	-
Subj 3	7	+	+	++	+	+	+	++	-
Subj 4	13	+	+	+	++	+	+	+	++
Subj 5	15	+	+	+	++	+	+	+	++
Subj 6	17	+	+	+	++	+	+	+	++
Animal No.	Days PI	Liver/Adrenal				Brain
		*Kup*	*Hep*	*Cort*	*End*	*Neur*	*Glial*	*Mac*	*End*
Subj 1	7	-	+	+	-	-	-	-	+
Subj 2	7	++	++	++	-	-	-	+	+
Subj 3	7	+	+	+	-	-	-	+	-
Subj 4	13	++	++	+++	++	-	-	++	++
Subj 5	15	++	+++	+++	++	-	-	++	++
Subj 6	17	++	++	+++	++	-	+	++	++

+ indicates that LASV antigen-positive cells were rarely detected; + + indicates that LASV-positive cells were occasionally detected; + + + indicates that LASV-positive cells were frequently detected; and - indicates that no LASV-positive cells were detected.
Mono = monocytes; Mac = macrophages; DC = dendritic cells; End = Endothelial cells; Kup = Kupffer cells; Hep = hepatocytes; Cort = adrenal cortical cells; Neur = Neurons.

ISSN: 1743-422X