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Figure 9 | Virology Journal

Figure 9

From: Pathogenesis of lassa fever in cynomolgus macaques

Figure 9

Histopathology and immunohistochemistry of nervous tissue of Lassa virus-infected cynomolgus monkeys. (A) Histology of cerebellum showing meningitis at day 15; H&E stain. (B) Histology of cerebrum showing neuronal necrosis at day 13; H&E stain. (C), Optic neuritis; note immunopositive inflammatory foci (brown) at day 15. (D), Brain stem, immunopositive endothelium (arrow) and immunopositive inflammatory foci (brown) in the neuropil peripheral to a medium-sized blood vessel at day 13. (E) Immunopositive endothelial cells (brown) in cerebrum at day 15. (F) Choroid plexus, prominent immunostaining (brown) of the cuboidal epithelial cells lining the choroid at day 15. Original magnifications, ×20 (B-F), ×40 (A)

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