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Table 2 Summary of predicted tyrosine phosphorylation sites.

From: Positional effect of phosphorylation sites 266 and 267 in the cytoplasmic domain of the E2 protein of hepatitis C virus 3a genotype: Interferon Resistance analysis via Sequence Alignment

Sitea

aab

Contextc

NetPhos d

Scansite e

NetSurfPf

I-TASSERg

66

*S*

ATTASVRSH

0.869

 

E

Yes

266

*S*

PRRLSSCKP

0.978

Y

E

Yes

267

*S*

RRLSSCKPI

0.983

Y

E

Yes

356

*S*

LRPPSGRWF

0.992

 

E

No

311

*T*

VKAATVCGP

0.512

 

E

No

  1. a) Phosphorylation sites in the local 3a sequences of the envelope genes.
  2. b) S indicates Serine; T is for Threonine and Y for Tyrosine predictions.
  3. c) Region where the phosphorylation sites are available.
  4. d) Predicted sites by NetPhos with a score of ≥ 0.8. Dashes indicate lack of Phosphorylation sites in that position.
  5. e) Y indicates predicted sites in sequence on "Low Stringency". Dashes indicate lack of Phosphorylation sites in that position.
  6. f) E indicates Exposed sites and B indicates Buried sites. Surface accessibility calculated by NetSurfP.
  7. g) Ab-initio 3D model was constructed by using I-TASSER server.
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Virology Journal

ISSN: 1743-422X