Skip to main content

Table 1 Mouse extracellular matrix and adhesion molecules gene(s) differentially expressed by two fold in VEEV infected CD 1 mouse brain.

From: Role of adhesion molecules and inflammation in Venezuelan equine encephalitis virus infected mouse brain

Position on Array Ref Sequence Number Functional Grouping (Gene) Fold expression over uninfected controls
    48 hr pi 72 hr pi 96 hr pi 120 hr pi
Cell Adhesion molecules: Transmembrane/cell-cell adhesion/cell-matrix adhesion/other molecules
9 NM_009851 CD44 antigen (Cd44) (A) 5.24 (PI) ± 4.24 (0.37) 16.35 (PI) ± 10.09 (0.20) 34.83 (PI) ± 3.23 (0.0004)
10 NM_009864 Cadherin 1 (Cdh1) 3.97 ± 0.32 (0.0007) 4.98 ± 3.37 (0.30) 6.52 ± 5.23 (0.35) 16.79 ± 1.57 (0.0005)
14 NM_009868 Cadherin 5 (Cdh5) (A) 1.17 (PI) ± 0.17 (0.37) 1.92 (PI) ± 0.59(0.19) 9.57 (PI) ± 0.97 (0.0009)
29 NM_016919 Procollagen, type V, alpha 3 (Col5a3) 0.81 ± 0.15 (0.51) 1.09 ± 0.19 (0.78) 1.60 ± 0.67 (0.16) 2.07 ± 0.31 (0.03)
32 NM_007739 Procollagen, type VIII, alpha 1 (Col8a1) 1.41 ± 0.49 (0.53) 1.77 ± 1.31(0.27) 1.18 ± 0.39 (0.70) 0.80 ± 0.61 (0.65)
34 XM_488510/
NM_001081249.1
Mus musculus chondroitin sulfate proteoglycan 2(Cspg2)/Versican (Vcan) 1.14 ± 0.40 (0.74) 2.36 ± 0.80 (0.28) 3.34 ± 1.13 (0.23) 4.39 ± 1.83 (0.07)
35 NM_010217 Connective tissue growth factor (Ctgf) 0.88 ± 0.13 (0.38) 0.91 ± 0.13 (0.52) 0.83 ± 0.05 (0.24) 0.45 ± 0.10 (0.01)
38 NM_009848 Ectonucleoside triphosphate diphosphohydrolase 1(Entpd1) (A) (A) (A) 4.37 (PI) ± 1.41 (0.03)
41 NM_013500 Hyaluronan and proteoglycan link protein 1 (Hapln1) 0.67 (PI) ± 0.29 1.15 (PI) ± 0.13 (0.73) (A) (A)
43 NM_010493 Intercellular adhesion molecule (Icam1) 2.82 (PI) ± 1.32 (0.24) 8.4 (PI) ± 3.00 (0.07) 13.51 (PI) ± 6.24 (0.12) 36.76 (PI) ± 4.81 (0.001)
56 NM_021334 Integrin alpha × (Itgax) (A) (A) 4.49 ± 1.12 (0.01) 3.55 (PI) ± 0.89 (0.02)
57 NM_010578 Integrin beta 1 (fibronectin receptor beta) (Itgb1) 1.06 ± 0.48 (0.83) 1.61 ± 0.35 (0.27) 2.41 ± 0.56 (0.02) 2.67 ± 0.39 (0.01)
58 NM_008404 Integrin beta 2 (Itgb2) (A) (A) (A) 4.79 (PI) ± 0.27 (0.0.0001)
59 NM_016780 Integrin beta 3 (Itgb3) 1.36 (PI) ± 0.25 (0.59) 2.32 (PI) ± 0.30 (0.10) 3.37 (PI) ± 1.32 (0.03) 3.06 (PI) ± 0.55 (0.01)
63 NM_013566 Integrin beta 7 (Itgb7) 0.83 ± 0.13 (0.50) (A) 3.40 ± 1.98 (0.27) 7.84 (PI) ± 3.04 (0.04)
96 NM_011346 Selectin, lymphocyte (Sell) 2.67 (PI) ± 0.89 (0.33) 10.06 (PI) ± 5.41 (0.08) 20.37(PI) ± 11.02 (0.07) 21.45 (PI) ± 5.60 (0.001)
97 NM_011347 Selectin, platelet (Selp) 12.66 (PI) ± 8.84 (0.26) 32.57 (PI) ± 2.66 (0.0002) 43.14 (PI) ± 5.70 (0.001) 37.60 (PI) ± 4.37 (0.001)
105 NM_011581 Thrombospondin 2 (Thbs2) 1.17 ± 0.34 (0.58) 1.60 ± 0.82 (0.44) 2.87 ± 1.58 (0.40) 4.02 ± 3.50 (0.39)
107 NM_011582 Thrombospondin 4 (Thbs4) 11.99 ± 3.25 (0.03) 2.70 ± 1.19 (0.22) 1.30 ± 0.30 (0.37) (A)
Extracellular Matrix Proteins: Basement membrane constituents/ECM proteases and their inhibitors/others
5 NM_013906 A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 (Adamts8) (A) 2.44 (PI) ± 0.34 (0.01) (A) 2.78 (PI) ± 0.41 (0.01)
16 NM_007729 Procollagen, type XI, alpha 1 (Col11a1) (A) 2.60 ± 1.61(0.37) (A) (A)
77 NM_008608 Matrix metallopeptidase 14 (membrane-inserted) (Mmp14) 0.51 ± 0.09 (0.05) 1.07 ± 0.12 (0.76) 1.32 ± 0.28 (0.11) 1.24 ± 0.20 (0.17)
78 NM_008609 Matrix metallopeptidase 15 (Mmp15) (A) (A) 2.48 ± 1.48 (0.37) (A)
79 NM_019724 Matrix metallopeptidase 16 (Mmp16) 0.49 ± 0.16 (0.09) 1.62 ± 0.07 (0.22) 0.68 ± 0.26 (.035) 1.18 ± 0.32 (0.65)
87 NM_010809 Matrix metallopeptidase 3 (Mmp3) 4.60 (PI) ± 3.34 (0.34) 29.25 (PI) ± 8.41 (0.03) 48.06 (PI) ± 2.98 (0.00009) 26.60 (PI) ± 5.76 (0.01)
89 NM_008611 Matrix metallopeptidase 8 (Mmp8) 1.21 ± 0.29 (0.46) (A) 6.15 ± 4.73 (0.38) 22.59 (PI) ± 6.94 (0.05)
101 NM_009263 Secreted phosphoprotein 1 (Spp1) 1.00 ± 0.03 (0.99) 0.67 ± 0.18 (0.12) 0.63 ± 0.17 (0.12) 0.50 ± 0.06 (0.01)
103 NM_009369 Transforming growth factor, beta induced (Tgfbi) 0.87 ± 0.10 (0.40) 0.55 ± 0.19 (0.15) 0.06 ± 0.04 (0.001) 0.08 ± 0.06 (0.001)
108 NM_011593 Tissue inhibitor of metalloproteinase 1 (Timp1) (A) 4.88 (PI) ± 2.38 (0.18) 17.64 (PI) ± 5.88 (0.05) 13.79 (PI) ± 1.36 (0.0007)
112 NM_011607 Tenascin C (Tnc) (A) (A) 0.49 ± 0.25 (0.37) (A)
  1. Genes that are differentially expressed by ≥2.0 fold are represented. Values are represented at mean fold difference ± SEM (P-value). (A) = absent; PI = present in infection and; PC = present in saline control.
\