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Table 1 Mouse extracellular matrix and adhesion molecules gene(s) differentially expressed by two fold in VEEV infected CD 1 mouse brain.

From: Role of adhesion molecules and inflammation in Venezuelan equine encephalitis virus infected mouse brain

Position on Array

Ref Sequence Number

Functional Grouping (Gene)

Fold expression over uninfected controls

   

48 hr pi

72 hr pi

96 hr pi

120 hr pi

Cell Adhesion molecules: Transmembrane/cell-cell adhesion/cell-matrix adhesion/other molecules

9

NM_009851

CD44 antigen (Cd44)

(A)

5.24 (PI) ± 4.24 (0.37)

16.35 (PI) ± 10.09 (0.20)

34.83 (PI) ± 3.23 (0.0004)

10

NM_009864

Cadherin 1 (Cdh1)

3.97 ± 0.32 (0.0007)

4.98 ± 3.37 (0.30)

6.52 ± 5.23 (0.35)

16.79 ± 1.57 (0.0005)

14

NM_009868

Cadherin 5 (Cdh5)

(A)

1.17 (PI) ± 0.17 (0.37)

1.92 (PI) ± 0.59(0.19)

9.57 (PI) ± 0.97 (0.0009)

29

NM_016919

Procollagen, type V, alpha 3 (Col5a3)

0.81 ± 0.15 (0.51)

1.09 ± 0.19 (0.78)

1.60 ± 0.67 (0.16)

2.07 ± 0.31 (0.03)

32

NM_007739

Procollagen, type VIII, alpha 1 (Col8a1)

1.41 ± 0.49 (0.53)

1.77 ± 1.31(0.27)

1.18 ± 0.39 (0.70)

0.80 ± 0.61 (0.65)

34

XM_488510/

NM_001081249.1

Mus musculus chondroitin sulfate proteoglycan 2(Cspg2)/Versican (Vcan)

1.14 ± 0.40 (0.74)

2.36 ± 0.80 (0.28)

3.34 ± 1.13 (0.23)

4.39 ± 1.83 (0.07)

35

NM_010217

Connective tissue growth factor (Ctgf)

0.88 ± 0.13 (0.38)

0.91 ± 0.13 (0.52)

0.83 ± 0.05 (0.24)

0.45 ± 0.10 (0.01)

38

NM_009848

Ectonucleoside triphosphate diphosphohydrolase 1(Entpd1)

(A)

(A)

(A)

4.37 (PI) ± 1.41 (0.03)

41

NM_013500

Hyaluronan and proteoglycan link protein 1 (Hapln1)

0.67 (PI) ± 0.29

1.15 (PI) ± 0.13 (0.73)

(A)

(A)

43

NM_010493

Intercellular adhesion molecule (Icam1)

2.82 (PI) ± 1.32 (0.24)

8.4 (PI) ± 3.00 (0.07)

13.51 (PI) ± 6.24 (0.12)

36.76 (PI) ± 4.81 (0.001)

56

NM_021334

Integrin alpha × (Itgax)

(A)

(A)

4.49 ± 1.12 (0.01)

3.55 (PI) ± 0.89 (0.02)

57

NM_010578

Integrin beta 1 (fibronectin receptor beta) (Itgb1)

1.06 ± 0.48 (0.83)

1.61 ± 0.35 (0.27)

2.41 ± 0.56 (0.02)

2.67 ± 0.39 (0.01)

58

NM_008404

Integrin beta 2 (Itgb2)

(A)

(A)

(A)

4.79 (PI) ± 0.27 (0.0.0001)

59

NM_016780

Integrin beta 3 (Itgb3)

1.36 (PI) ± 0.25 (0.59)

2.32 (PI) ± 0.30 (0.10)

3.37 (PI) ± 1.32 (0.03)

3.06 (PI) ± 0.55 (0.01)

63

NM_013566

Integrin beta 7 (Itgb7)

0.83 ± 0.13 (0.50)

(A)

3.40 ± 1.98 (0.27)

7.84 (PI) ± 3.04 (0.04)

96

NM_011346

Selectin, lymphocyte (Sell)

2.67 (PI) ± 0.89 (0.33)

10.06 (PI) ± 5.41 (0.08)

20.37(PI) ± 11.02 (0.07)

21.45 (PI) ± 5.60 (0.001)

97

NM_011347

Selectin, platelet (Selp)

12.66 (PI) ± 8.84 (0.26)

32.57 (PI) ± 2.66 (0.0002)

43.14 (PI) ± 5.70 (0.001)

37.60 (PI) ± 4.37 (0.001)

105

NM_011581

Thrombospondin 2 (Thbs2)

1.17 ± 0.34 (0.58)

1.60 ± 0.82 (0.44)

2.87 ± 1.58 (0.40)

4.02 ± 3.50 (0.39)

107

NM_011582

Thrombospondin 4 (Thbs4)

11.99 ± 3.25 (0.03)

2.70 ± 1.19 (0.22)

1.30 ± 0.30 (0.37)

(A)

Extracellular Matrix Proteins: Basement membrane constituents/ECM proteases and their inhibitors/others

5

NM_013906

A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 (Adamts8)

(A)

2.44 (PI) ± 0.34 (0.01)

(A)

2.78 (PI) ± 0.41 (0.01)

16

NM_007729

Procollagen, type XI, alpha 1 (Col11a1)

(A)

2.60 ± 1.61(0.37)

(A)

(A)

77

NM_008608

Matrix metallopeptidase 14 (membrane-inserted) (Mmp14)

0.51 ± 0.09 (0.05)

1.07 ± 0.12 (0.76)

1.32 ± 0.28 (0.11)

1.24 ± 0.20 (0.17)

78

NM_008609

Matrix metallopeptidase 15 (Mmp15)

(A)

(A)

2.48 ± 1.48 (0.37)

(A)

79

NM_019724

Matrix metallopeptidase 16 (Mmp16)

0.49 ± 0.16 (0.09)

1.62 ± 0.07 (0.22)

0.68 ± 0.26 (.035)

1.18 ± 0.32 (0.65)

87

NM_010809

Matrix metallopeptidase 3 (Mmp3)

4.60 (PI) ± 3.34 (0.34)

29.25 (PI) ± 8.41 (0.03)

48.06 (PI) ± 2.98 (0.00009)

26.60 (PI) ± 5.76 (0.01)

89

NM_008611

Matrix metallopeptidase 8 (Mmp8)

1.21 ± 0.29 (0.46)

(A)

6.15 ± 4.73 (0.38)

22.59 (PI) ± 6.94 (0.05)

101

NM_009263

Secreted phosphoprotein 1 (Spp1)

1.00 ± 0.03 (0.99)

0.67 ± 0.18 (0.12)

0.63 ± 0.17 (0.12)

0.50 ± 0.06 (0.01)

103

NM_009369

Transforming growth factor, beta induced (Tgfbi)

0.87 ± 0.10 (0.40)

0.55 ± 0.19 (0.15)

0.06 ± 0.04 (0.001)

0.08 ± 0.06 (0.001)

108

NM_011593

Tissue inhibitor of metalloproteinase 1 (Timp1)

(A)

4.88 (PI) ± 2.38 (0.18)

17.64 (PI) ± 5.88 (0.05)

13.79 (PI) ± 1.36 (0.0007)

112

NM_011607

Tenascin C (Tnc)

(A)

(A)

0.49 ± 0.25 (0.37)

(A)

  1. Genes that are differentially expressed by ≥2.0 fold are represented. Values are represented at mean fold difference ± SEM (P-value). (A) = absent; PI = present in infection and; PC = present in saline control.