Table 4 Sequence similarities and characterization of of Madine Darby Canine Kidney Cells (MDCK)

Gibberella moniliformis p450-4 gene for ent-kaurene oxidase, exons 1-4, strain A-00149 (up regulated)

100%

Responsible for the synthesis of plant terpenoids.

Pongo abelii reticulon 4 (RTN4), mRNA >emb|CR861110.1| Pongo abelii mRNA; cDNA DKFZp459C0314 (from clone DKFZp459C0314) (down regulated)

90%

Protein that in humans is encoded by the RTN4 gene that has been identified as an inhibitor of neurite outgrowth specific to the central nervous system. It is also known to interact with Bcl-2 gene which is involved in promoting and inhibiting apoptosis in cells during stress.

Homo sapiens amyloid beta (A4) precursor protein, mRNA (cDNA clone IMAGE:4126584), (down regulated)

94%

Neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients

Influenza A virus (A/open-billed stork/Nakhonsawan/BBA0627 May/05(H5N1)) polymerase PA (PA) gene, complete cds (up regulated)

99%

Subunit of the trimeric complex of the RN polymerase of Influenza A, involved in tra RNAs

unknown gene (down regulated)

PREDICTED: Canis familiaris similar to ribosomal protein L14, transcript variant 2 (LOC480789), mRNA (down regulated)

100%

Encodes a ribosomal protein that is a compon Involved in transcription

Tigriopus japonicus mitochondrial heat shock protein 60 (Hsp60) mRNA, complete cds; nuclear gene for mitochondrial product (up regulated)

100%

Mitochondrial chaperonin that is typically transportation and refolding of proteins fr mitochondrial matrix. Involved in stre especially during infection.

TPA: TPA_inf: Canis familiaris RTN4-Cw (RTN4) gene, 3' UTR (up regulated)

99%

Inhibitor of neurite outgrowth specific to t system.

PREDICTED: Equus caballus similar to cyclin D2 (LOC100051150), mRNA (down regulated)

94%

Belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of cyclin-dependent kinases. Forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. Involved in the phosphorylation of tumor suppressor protein Rb

Mouse mRNA for amyloid beta precursor (protease nexin II) (up regulated)

95%

Up regulated during neuronal differentiati neural injury.

unknown gene (down regulated)

Bos taurus reticulon 4 (RTN4), transcript variant 1, mRNA > gb|AY164744.2| Bos taurus RTN4-C (RTN4) mRNA, complete cds (up regulated)

88%

Inhibitor of neurite outgrowth specific to the central nervous system