Schematic representation of the locations of the peptides on the structures of HSV-1 and MDV gB. (left) Three-dimensional structure of HSV-1 gB ectodomain. The structural coordinates were obtained from http://www.pdb.org/pdb/home/home.do. The structure is designated as 2GUM in the PDB and was visualized using the visual molecular dynamics program at http://www.ks.uiuc.edu/Research/vmd. (right) Predicted three-dimensional structure of the MDV gB ectodomain. The homology model of MDV gB was predicted by modelling against the known structure for HSV-1 gB using Swiss-Model via the ExPASy Web server http://swissmodel.expasy.org. Five domains observed in the crystal structure are highlighted in different colours and the corresponding positions of gBH1, H2, H3, and H4 are shown.