Skip to main content

Table 3 Sites under differential selection between isolates from seasonal human and the pandemic 2009 clusters

From: Positive selection on hemagglutinin and neuraminidase genes of H1N1 influenza viruses

Protein Position1 P-value Amino acid polymorphism2
    Pandemic 2009 strains Seasonal human strains
HA 34BT 0.00286 E1886/G2/X2/K1 E1404
  39 0.00054 G1887/E3/R1 G1404
  86B 0.00233 D1856/G31/N2/Y1/E1 E1383/K19/G1/Q1
  94B 0.00014 D1885/N4/E1/X1 Y769/H574/D38/N19/Q2/A1/R1
  153BT 0.00786 K1891 G1132/E202/R28/K20/X18/V4
  160BG 0.00073 K1890/E1 N1345/K27/X12/S7/T7/D2/E2/A1/I1
  187BR 0.00445 D1884/G5/X2 D1072/X135/N132/V30/E23/G9/A2/I1
  197 0.00073 A1851/T23/S17 A1401/T3
  202B 0.00318 G1886/X4/W1 V1378/L17/A5/M4
  203 0.00828 T1341/S542/X7/A1 S1392/T10/F1/X1
  224B 0.00973 E1885/Q1/X5 E1342/A45/H5/P5/K4/T2/S1
  234 0.00628 V1883/I7/L1 L1404
  237B 0.00445 G1890/X1 G1379/R19/E6
  250T 0.00002 V1884/I4/A2/L1 A1404
  282 0.00653 P1872/L10/S7/T1/X1 P1404
  302B 0.00098 K1880/E8/N1/T1/R1 E1403/G1
  339 0.00174 G1888/R2/E1 G1404
  374 0.00550 E1608/K275/G8 G1398/R4
  391 0.00564 T1888/A2/I1 T1404
  399 0.00303 H1890/X1 K1383/N16/R3/E1/T1
  430T 0.00605 E1889/D1/K1 E1404
  473T 0.00803 N1890/D1 D1001/N403
  527T 0.00513 V1873/I12/A2/L2/X2 L1403/V1
  541T 0.00052 G1866/W12/H6/M3/Y1/-3 G1404
NA 2 0.00001 N1313/-79/I2/S1/X1 N1532/-200/K3
  6 0.00009 K1350/-42/N3/R3 K1634/R14/-87
  35 0.00151 S1392/G2/C1/I1/V1 S1733/N1/G1
  52TG 0.00510 S1397 R1686/K17/S17/N9/G4/X1/-1
  254 0.00188 K1396/X1 K1581/R154
  257 0.00119 R1388/K8/X1 K1735
  1. 1In this column, B indicates that the site lies in the B-cell antigenic regions [18]. G means that it is a potential glycosylation site. T indicates that the site lies in the T-cell antigenic regions [19]. R indicates that it is a receptor-binding site [11]. We use the same numbering strategy for HA as Deem and Pan [18] and start numbering from the amino acids DTLC. The NA numbering starts from MNPN.
  2. 2In these columns, capital letters stand for amino acids and numbers following them indicate the number of times they occur in the alignment. X indicates codons that are not translated properly.