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Table 4 Comparison of demographic, biochemical parameters as well as Complications and mortality frequencies among patients infected with genotype 4 HEV with and without liver cirrhosis

From: Clinical characteristics and risk factors of sporadic Hepatitis E in central China

Parameter

HEV

P value

Number of patients

40

170

-

Age in years

51.78 ± 14.70

48.02 ± 14.55

NS

Gender(male/female)

36/4

143/27

NS

Mortality

10(25%)

11(6.47%)

0.002

Complications

   

Spontaneous peritonitis

24(60%)

14(8.24%)

< 0.001

Upper gastrointestinal hemorrhage

2(5%)

4(2.35%)

NS

Hepatorenal syndrome

8(20%)

5(2.94%)

< 0.001

Hepatic encephalopathy

6(15%)

8(4.71%)

0.03

ALT(U/L)

574.5(150.25-1612.25)

1158(478.75-1816.75)

0.02

AST(U/L)

310.5(117-1198.5)

670.5(208-1265.2)

NS

GGT(U/L)

85(52.5-114.75)

131(67-229)

0.002

TBil(umol/L)

242.6(115.6-530.3)

197.93(82.6-298.85)

NS

ALB(g/L)

31(27.65-32.98)

34.1(31.58-37.8)

< 0.001

Tchol(mmol/L)

2.17(1.71-3.27)

3.18(2.45-3.9)

< 0.001

CHE(U/L)

3014.5(2125.75-3967)

4356(3039.25-5752.25)

0.001

BUN (mmol/L)

5.5(4-9.29)

4.65(3.64-6)

0.032

Cr(umol/L)

64.9(55.35-116.6)

65.5(56.2-78.8)

NS

PTA(%)

63(42-85)

93(72.95-113.5)

< 0.001

INR

1.41(1.19-1.75)

1.13(1.04-1.29)

< 0.001

  1. HEV, hepatitisE virus; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyltransferase; TBil, total bilirubin; ALB, albumin; ALP, alkaline phosphatase; Tchol, total cholesterol; LDH, lactate dehydrogenase; CHE, cholinesterase; BUN, blood urea nitrogen; Cr, creatinine; PTA, prothrombin activity; INR, international normalized ratio; and NS, not significant