HIV integrase variability and genetic barrier in antiretroviral naïve and experienced patients

Piralla, Antonio; Paolucci, Stefania; Gulminetti, Roberto; Comolli, Giuditta; Baldanti, Fausto

doi:10.1186/1743-422X-8-149

Virology Journal

Table 3 Codon distribution and calculated genetic barrier at 27 integrase inhibitor susceptible positions in HIV-1 INI-naïve patients

From: HIV integrase variability and genetic barrier in antiretroviral naïve and experienced patients

IN codon position	Substitution	Wild type codon	Codon % distribution		Mutational resistance codon	Lower score	IN codon position	Substitution	Wild type codon	Codon % distribution		Mutational resistance codon	Lower scores
			HAART-naïve (n = 41)	RTI/PI-experienced (n = 54)						HAART-naïve (n = 41)	RTI/PI-experienced (n = 54)
51	H51Y	CAT	98	100	TAT	1	143	Y143C	TAC	90	90	TGC	1
		CAC	2	0	TAC	1			TAT	10	10	TGT	1
66	T66I	ACA	98	94	ATA	1		Y143R	TAC	90	90	CGC	2
		ACC	0	6	ATC	1			TAT	10	10	CGT	2
		ACG	2	0	ATA	2	146	Q146P	CAA	98	98	CCG	2.5
72	V72I	GTT	32	31	ATT	1			CAG	2	2	CCA	2.5
		GTC	15	6	ATC	1		Q146K	CAA	98	98	AAA	2.5
		GTA	0	6	ATA	1			CAG	2	2	AAG	2.5
		GTG	0	4	ATA	2	147	S147G	AGT	76	70	GGT	1
	I72	ATT	41	45		0			AGC	24	30	GGC	2
		ATC	12	2		0	148	Q148H	CAA	80	96	CAT/C	2.5
		ATA	0	4		0			CAG	20	4	CAT/C	2.5
	D72	GAT	0	2	ATT	3.5		Q148K	CAA	80	96	AAA	2.5
74	L74I	CTG	72	78	ATA	3.5			CAG	20	4	AAG	2.5
		CTA	10	15	ATA	2.5		Q148R	CAA	80	96	CGA	1
		TTA	10	2	ATA	2.5			CAG	20	4	CGG	1
		TTG	2	0	ATA	3.5	151	V151I	GTA	71	72	ATA	1
	I74	ATT	0	0		0			GTG	29	28	ATA	2
		ATA	2	7		0	153	S153Y	TCT	76	87	TAT	2.5
	M74	ATG	2	0	ATA	1			TCC	15	11	TAC	2.5
92	E92Q	GAA	63	61	CAA	2.5			TCA	7	2	TAT/C	5
		GAG	37	39	CAG	2.5		A153	GCC	2	0	TAC	5
95	Q95K	CAA	32	28	AAA	2.5	155	N155H	AAT	90	93	CAT	2.5
		CAG	68	70	AAG	2.5			AAC	10	7	CAC	2.5
	R95	CGG	0	2	AAG	3.5		N155S	AAT	90	93	AGT	1
97	T97A	ACA	98	96	GCA	1			AAC	10	7	AGC	1
	A97	GCA	0	4		0	157	E157Q	GAA	88	91	CAA	2.5
	S97	TCA	2	0	GCA	2.5			GAG	7	7	CAG	2.5
121	F121Y	TTC	90	98	TAC	2.5		Q157	CAA	5	2		0
		TTT	10	2	TAT	2.5	160	K160D	AAA	85	93	GAT/C	3.5
125	T125K	ACA	27	18	AAG	2.5			AAG	11	5	GAT/C	3.5
		ACT	10	4	AAA/G	5		R160	AGA	2	0	GAT	4.5
		ACG	12	24	AAG	2.5		Q160	CAA	2	2	GAT/C	5
	A125	GCA	44	33	AAA	3.5	163	G163R	GGA	63	57	AGA	1
		GCG	2	6	AAG	3.5			GGG	27	39	AGG	1
		GCT	0	6	AAA/G	6			GGT	0	2	CGC,AGA/G	3.5
	V125	GTG	0	7	AAG	3.5		E163	GAA	0	4	AGA	2
		GTA	2	0	AAA	3.5		N163	AAC	0	2	CGC,AGA/G	3.5
	M125	ATG	2	0	AAG	2.5		A163	GCG	0	2	CTG,AGG	3.5
	P125	CCG	0	2	AAG	5	165	V165I	GTA	56	52	ATA	1
128	A128T	GCA	54	50	ACA	1			GTC	22	18	ATC	1
		GCC	37	46	ACC	1			GTT	2	10	ATT	1
		GCT	9	4	ACT	1			GTG	0	2	ATA	2
138	E138K	GAA	100	98	AAA	1		I165	ATA	20	18		0
	D138	GAC	0	2	AAA/G	3.5	201	V201I	GTA	24	28	ATA	1
140	G140S	GGA	46	37	AGT/C	3.5			GTG	2	2	ATA	2
		GGC	44	46	AGC	1		I201	ATA	74	70		0
		GGT	5	6	AGT	1	203	I203M	ATA	95	98	ATG	1
		GGG	5	9	AGT/C	3.5		M203	ATG	5	2		0
	G140A	GGA	46	37	GCA	2.5	230	S230R	AGC	90	96	AAC	1
		GGC	44	46	GCC	2.5		N230	AAC	10	4		0
		GGT	5	6	GCT	2.5	263	R263K	AGA	85	96	AAA	1
		GGG	5	6	GCT/G	2.5			AGG	15	4	AAG	1

The amino acids differing from wild-type or expected mutant are in boldface.

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ISSN: 1743-422X

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