From: HIV integrase variability and genetic barrier in antiretroviral naïve and experienced patients
Mutation categories | Known amino acid substitution | Rate of INI resistance mutations in INI-naïve patients (%) | HIV-1 amino acid substitution | HIV-2 clade A ROD subtype consensus | HIV-2 substitution (4 strains) | |
---|---|---|---|---|---|---|
HAART-naïve (n = 41) | RTI/PI-experienced (n = 54) | |||||
Primary | E92Q | E | ||||
mutations | F121Y | F | ||||
E138A | S | T3 | ||||
G140A/S | G | |||||
Y143R7C/H | Y | |||||
S147G | S | |||||
Q148H/R/K | Q | |||||
S153Y | A 1 | A | ||||
N155H | N | |||||
R263K | R | |||||
Secondary mutations | H51Y | H | ||||
T66I | T | |||||
L74A/M/I | 7 (7.4) | I2/M1 | I4 | I | ||
Q95K | R 1 | R | ||||
T97A | 2 (2.1) | S 1 | A2 | T | ||
E138K | D 1 | S | T3 | |||
Q146P | N | |||||
V151I | V | |||||
E157Q | 3 (3.2) | Q2 | Q1 | H | ||
G163R | E 2 /N 1 /A 1 | S | G2 | |||
I203M | 3 (3.2) | M2 | M1 | M | ||
S230R/M | N 4 | N 2 | G | |||
Polymorphic and non-polymorphic mutations | V72I | 50 (52.6) | I22 | I28/D 1 | I | V2 |
T125K | A 19 /M 1 /V 1 | A 24 /V 4 /P 1 | E | D2 | ||
A128T | M | |||||
K160D | Q 1 /R 1 | Q 1 | N | |||
V165I | 18 (18.9) | I8 | I10 | I | ||
V201I | 68 (71.6) | I30 | I38 | I |