The full genome sequence of three strains of Jamestown Canyon virus and their pathogenesis in mice or monkeys

Table 6 JCV/61/CO-cl infection of rhesus monkeys results in detectable viremia and a high level of neutralizing antibody

	Virus titer on indicated day (log₁₀ PFU/mL)^a		Serum neutralizing antibody titer on day 28 as assayed against indicated virus^b
Monkey #	2	4	JCV/61/CO-cl	JCV/03/CT-cl	JCV/04/CT-cl
A5E054	0.7	< 0.7	195	64	505
A5E060	< 0.7	< 0.7	253	72	464
A5E068	< 0.7	< 0.7	260	165	571
A5E069	2.2	< 0.7	181	97	201
A5E070	2.5	< 0.7	172	78	205
A5E073	2.5	2.0	166	73	195
A5E077	3.0	< 0.7	180	83	244
DBXG	1.9	1.9	62	18	78
		GMT^c:	171	71	259

^a Serum was collected on days 0, 2, 4, 5, 8, 10, and 12. Virus was only detectable on days 2 and 4 with a lower limit of detection of 0.7 log₁₀ PFU/mL.
^b Reciprocal plaque reduction neutralization titer 60% (PRNT₆₀).
^c Geometric mean titer.

ISSN: 1743-422X