Skip to main content

Table 3 Tahyna virus is highly infectious and neurovirulent for weanling Swiss Webster mice, but strains differ in neuroinvasiveness

From: Tahyna virus genetics, infectivity, and immunogenicity in mice and monkeys

  Neuroinvasivenessa (log10PFU) Neurovirulenceb (log10PFU) Phenotypee
Virus LD50c ID50d LD50 ID50 Neuroinvasive Neurovirulent
TAHV/58/CZ 3.5 3.5 0.5 0.5 Low High
TAHV/58/CZ-cl(1) 1.5 1.4 0.7 0.7 High High
TAHV/58/CZ-cl(2) >5 4.5 0.8 0.8 Low High
TAHV/68/FR >5 4.4 0.7 0.7 Low High
TAHV/68/FR-cl >5 2.6 0.9 0.9 Low High
TAHV/84/CZ >5 4.6 1.1 1.1 Low High
TAHV/84/CZ-cl >5 3.5 0.3 0.3 Low High
  1. a Groups of weanling Swiss Webster mice (21-23 days old) were inoculated intraperitoneally with 100 μL of diluted virus (0 - 5 log10 PFU).
  2. b Groups of weanling Swiss Webster mice (21-23 days old) were inoculated intracerebrally with 10 μL of diluted virus (1 - 4 log10 PFU).
  3. c LD50 = Lethal dose 50%.
  4. d ID50 = Infectious dose 50%.
  5. e Neuroinvasive phenotype: Low = LD50 ≥ 3.5 log10 PFU; High = LD50 ≤ 1.5 log10 PFU. Neurovirulent phenotype: High = LD50 < 1.5 log10 PFU.