Table 2 Genetic analysis of amino acids at HA cleavage site and receptor binding sites of H4 gene of three H4 isolates in this study and reference H4N6 and H4N9 virus
From: Genetic characterization of avian influenza subtype H4N6 and H4N9 from live bird market, Thailand
| Â | HA cleavage | Receptor-binding site | ||||||
|---|---|---|---|---|---|---|---|---|
H3 numbering system* | 320-329 | 98 | 153 | 155 | 183 | 190 | 194 | 195 |
H4 position | 338-343 | 110 | 165 | 167 | 196 | 203 | 207 | 208 |
A/Dk/TH/CU-LM1973/09 (H4N6) | PEKASR | Y | W | V | H | E | L | Y |
A/Dk/TH/CU-LM1983/09 (H4N6) | PEKASR | Y | W | V | H | E | L | Y |
A/Dk/TH/CU-LM1984/09 (H4N9) | PEKASR | Y | W | V | H | E | L | Y |
A/Dk/Czech/1/56 (H4N6) | PEKASR | Y | W | V | H | E | L | Y |
A/Muskrat/Buryatiya/1944/00 (H4N6) | PEKAPR | Y | W | V | H | E | L | Y |
A/mallard/Yan Chen/2005 (H4N6 | PEKASR | Y | W | V | H | E | L | Y |
A/turnstone/NJ/47/85 (H4N6) | PEKATR | Y | W | T | H | E | L | Y |
A/mallard/Alberta/49/1995(H4N6) | PEKATR | Y | W | T | H | E | L | Y |
A/Sw/ON/01911-1/99 (H4N6) | PEKATR | Y | W | T | H | E | L | Y |
A/Dk/NY/180/86 (H4N9) | PEKATR | Y | W | T | H | E | L | Y |
| Â | Â | Left edge of receptor-binding site | ||||||
H3 numbering system | Â | 224 | 225 | 226 | 227 | 228 | 229 | Â |
H4 position | Â | 237 | 238 | 239 | 240 | 241 | 242 | Â |
A/Dk/TH/CU-LM1973/09 (H4N6) | Â | R | G | Q | S | G | R | Â |
A/Dk/TH/CU-LM1983/09 (H4N6) | Â | R | G | Q | S | G | R | Â |
A/Dk/TH/CU-LM1984/09 (H4N9) | Â | R | G | Q | S | G | R | Â |
A/Dk/Czech/1/56 (H4N6) | Â | R | G | Q | S | G | R | Â |
A/Muskrat/Buryatiya/1944/00 (H4N6) | Â | R | G | Q | S | G | R | Â |
A/mallard/Yan Chen/2005 (H4N6 | Â | R | G | Q | S | G | R | Â |
A/turnstone/NJ/47/85 (H4N6) | Â | R | G | Q | S | G | R | Â |
A/mallard/Alberta/49/1995(H4N6) | Â | R | G | Q | S | G | R | Â |
A/Sw/ON/01911-1/99 (H4N6) | Â | R | G | L | S | S | R | Â |
A/Dk/NY/180/86 (H4N9) | Â | R | G | Q | S | G | R | Â |
| Â | Â | Right edge of receptor-binding site | ||||||
H3 numbering system | Â | 134 | 135 | 136 | 137 | 138 | Â | Â |
H4 position | Â | 146 | 147 | 148 | 149 | 150 | Â | Â |
A/Dk/TH/CU-LM1973/09 (H4N6) | Â | G | K | S | G | A | Â | Â |
A/Dk/TH/CU-LM1983/09 (H4N6) | Â | G | K | S | G | A | Â | Â |
A/Dk/TH/CU-LM1984/09 (H4N9) | Â | G | K | S | G | A | Â | Â |
A/Dk/Czech/1/56 (H4N6) | Â | G | K | S | G | A | Â | Â |
A/Muskrat/Buryatiya/1944/00 (H4N6) | Â | G | K | S | G | A | Â | Â |
A/mallard/Yan Chen/2005 (H4N6 | Â | G | K | S | G | A | Â | Â |
A/turnstone/NJ/47/85 (H4N6) | Â | G | K | S | G | A | Â | Â |
A/mallard/Alberta/49/1995(H4N6) | Â | G | K | S | G | A | Â | Â |
A/Sw/ON/01911-1/99 (H4N6) | Â | G | K | S | G | A | Â | Â |
A/Dk/NY/180/86 (H4N9) | Â | G | K | S | G | A | Â | Â |