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Table 2 Immunogenicity of recombinant YF 17D viruses in A/J mice

From: Biological and immunological characterization of recombinant Yellow Fever 17D Viruses expressing a Trypanosoma cruzi Amastigote Surface Protein-2 CD8+T cell epitope at two distinct regions of the genome

Immunogen a Animals (n) PRNT 50 a Protection after YF17D challenge (%)
   1 dose 2 doses  
YF 17DD 15 358 ± 119 1007 ± 243 100
YF17D/E200/Tc 15 41 ± 12* 124 ± 67** NTb
YF17D/NS2B3/Tc 15 90 ± 20* 274 ± 240** 100
199 Earle's Medium 15 < 10 < 10 -
  1. aReciprocal of the dilution yielding 50% plaque reduction due to neutralizing antibodies in the serum analyzed. Values represent mean of three independent experiments (pooled serum) ± standard deviation (SD). * first and **second dose titers displaying statistically significant differences related to YF17DD group (P < 0.05, Tukey's test)
  2. b NT; Not tested