Figure 1
From: Antibody dependent enhancement infection of Enterovirus 71 in vitro and in vivo
ADE infection of EV71 in THP-1 cells mediated by different concentrations of IVIG. Serial 10-fold IVIG dilutions were pre-mixed with EV71 and then cultured in THP-1 cell for 24 h. (A) Plaque forming assay of viral yield in THP-1 cells at 24 h post infection. 100 dilutions of IVIG treatment completely block EV71 replication in THP-1 cells, an enhancement of viral yield was observed at 10-3 dilutions compared with the PBS control and 10-2 or 10-4 dilutions. (B) The dose range of enhancement of EV71 infection by IVIG. The error bars represent the standard deviations of three independent experiments.