Figure 2

Structural prediction workflow. Structural similarities from Dali and known interactions between human proteins from HPRD are used to predict interactions between HIV-1 and human proteins. These predictions are filtered based on functional information from previous studies to make a first set of predictions. This set is further filtered using GO cellular component terms to yield a final prediction set including fewer predictions with higher confidence. Numbers represent the number of interactions, or structural similarities in the case of Dali, at each stage of the process.