Figure 4

Upper panel shows the sequential measurement of VL (%; solid line) and CD4T-cell number/μL (broken line) in symptomatic cases 3 and 5. Lower panel shows SBH status at the same time as VL assays. In case 3, the first SBH gave dense smears (black arrow, Eco-R1 digestion) and an indeterminate clonal band (red arrow, Pst1 digestion), and then dense smears disappeared followed by clear visualization of a clonal band. In case 5, when dense smears emerged, the VL was the highest, and after disappearance, the clonal band and level of VL stably persisted.