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Figure 2 | Virology Journal

Figure 2

From: Keratin 18 phosphorylation as a progression marker of chronic hepatitis B

Figure 2

K18 phosphorylation in relation to histological progression of CHB. (A) Representative immunoblots of indicated proteins from a control (lane C), inactive (lanes 1-4) and active (lanes 5-8) cirrhotic livers. (B) Representative immunoblots of indicated proteins from livers with progressive histological lesions, MiH (lanes 1-3), MeH (lanes 4-6) and AdH (lanes 7-9), minimal, medium and advanced histological lesions, respectively. (C) The box and whisker plot of the relative levels of Ser33 phosphorylation of K18 in livers of the normal donors, and patients with CHB at different progression stages. Three outliers are indicated by open dots. Significant difference (P < 0.005) was observed in any pair with the exception of MiH vs. inactive LC (liver cirrhosis, P = 0.750), and AdH vs. active LC (P = 0.715), respectively. (D) The box whisker plot of relative levels of Ser52 phosphorylation of K18 in livers from indicated sources. The four outliers are indicated by open dots. Significant difference (P < 0.05) was observed in any pair with the exception of normal vs. MiH (P = 0.168), and AdH vs. inactive LC (P = 0.289), respectively.

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