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Table 1 Summary of IN mutant chromatin/LEDGF binding phenotypes

From: Characterization of the HIV-1 integrase chromatin- and LEDGF/p75-binding abilities by mutagenic analysis within the catalytic core domain of integrase

 

Conservations *

Mutations

Chromatin binding

Interaction with LEDGF/p75

Wild type

 

Wild type

+++

+++

D64/D116

99.4/99.7

DD64, 116EA

+++

++

K136

31.3

K136A

+++

++

K159

99.5

K159P

-

+/-

V165

93.5

V165A

-

-

E170

99.6

H171A

+++

-

H171

98.5

L172A

+++

-

L172

99.4

EH170,1AA

++

-

K173

96.9

EK170,3AA

+++

+++

V176

99.4

HL171,2AA

-

-

A179

99.8

HK171,3AA

++

++

I182

98.0

V176A

-

-

F185

99.4

A179P

-

-

KR186,7

99.7/99.0

A179I

-

NA

I200

98.3

I182A

+

++

I203

96.8

F185A

+

++

 

KR186,7AA

-

-

 

I200A

+

-

 

I203A

+++

++

 

I203P

-

-

  1. * Percent identify at that position among a collection of 1242 HIV-1 and SIVcpz strains http://www.hiv.lanl.gov.