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Table 1 Summary of IN mutant chromatin/LEDGF binding phenotypes

From: Characterization of the HIV-1 integrase chromatin- and LEDGF/p75-binding abilities by mutagenic analysis within the catalytic core domain of integrase

  Conservations * Mutations Chromatin binding Interaction with LEDGF/p75
Wild type   Wild type +++ +++
D64/D116 99.4/99.7 DD64, 116EA +++ ++
K136 31.3 K136A +++ ++
K159 99.5 K159P - +/-
V165 93.5 V165A - -
E170 99.6 H171A +++ -
H171 98.5 L172A +++ -
L172 99.4 EH170,1AA ++ -
K173 96.9 EK170,3AA +++ +++
V176 99.4 HL171,2AA - -
A179 99.8 HK171,3AA ++ ++
I182 98.0 V176A - -
F185 99.4 A179P - -
KR186,7 99.7/99.0 A179I - NA
I200 98.3 I182A + ++
I203 96.8 F185A + ++
  KR186,7AA - -
  I200A + -
  I203A +++ ++
  I203P - -
  1. * Percent identify at that position among a collection of 1242 HIV-1 and SIVcpz strains http://www.hiv.lanl.gov.